Fototerapia no tratamento da mucosite oral

uma revisão de literatura

Autores

DOI:

https://doi.org/10.7308/aodontol/2019.55.e11

Palavras-chave:

Estomatite, Fototerapia, Lasers, Terapia com luz de baixa intensidade

Resumo

Objetivo: O presente estudo tem por objetivo relatar as características da mucosite oral e o efeito da fototerapia no tratamento desta condição.

Métodos: Realizou-se uma pesquisa bibliográfica nas bases de dados eletrônicas Web of Science, Scopus, PubMed e Scielo. A estratégia de busca foi baseada na pesquisa dos descritores “LLLT”, “Low-Level Laser Therapy”, “Light, phototherapy”, “phototherapy”, “Photobiomodulation Therapy” “Photobiostimulation Laser Irradiation”, “Laser”, “Mucositis” e “Oral Mucositis”.

Resultados: Após a análise dos artigos completos, 22 artigos foram considerados adequados para serem incluídos na revisão, sendo um publicado em 2012 (4,5%), um em 2013 (4,5%), dois em 2015 (9,1%), dois em 2016 (9,1%), quatro em 2017 (18,2%), nove em 2018 (40,9%) e três em 2019 (13,7%).

Conclusão: Pode-se concluir que a laserterapia é eficaz na prevenção e tratamento da mucosite oral induzida por quimioradioterapia, reduzindo a dor e promovendo a cicatrização tecidual.

Downloads

Não há dados estatísticos.

Referências

Elad S, Zadik Y. Chronic oral mucositis after radiotherapy to the head and neck: a new insight. Support Care Cancer. 2016;24(11):4825-30.

Zecha JAEM, Raber-Durlacher JE, Nair RG, Epstein JB, Elad S, Hamblin MR, et al. Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part2: proposed applications and treatment protocols. Support Care Cancer. 2016;24:2793-805.

Bayer S, Kazancioglu HO, Acar AH, Demirtas N, Kandas NO. Comparison of laser and ozone treatments on oral mucositis in an experimental model. Lasers Med Sci. 2017;32(3):673-7.

Carvalho CG, Medeiros-Filho JB, Ferreira MC. Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence. Support Care Cancer. 2018;26(8):2651-61.

Marín-Conde F, Castellanos-Cosano L, Pachón-Ibañez J, Serrera-Figallo MA, Gutiérrez-Pérez JL, Torres-Lagares D. Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial. Int J Oral Maxillofac Surg. 2019;48(7):917-23.

Silva Júnior, Gordón-Núñez MA, Galvão HC, Costa EMMB. Mucosite oral induzida por radiação: uso de fatores de crescimento e de laser. RGO, Rev. Gaúch. Odontol. 2010;58(4):511-4.

Khouri V, Pereyra A, Rodriguez D, Pieroni F, Pinto B, Voltarelli J. Use of therapeutic laser for prevention and treatment of oral mucositis. Braz Dent J. 2009;20(3):215-20.

Amadori F, Bardellini E, Conti G, Pedrini N, Schumacher RF, Majorana A. Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in childhood: a randomized double-blind controlled study. Lasers Med Sci. 2016;31;(6):1231-6.

Eduardo FP, Bezinelli LM, Lopes RMG, Nascimento Sobrinho JJ, Hamerschlak N, Correa L. Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study. Hematol Oncol. 2015;33(3):152-8.

Rezazadeh F, Hajian K, Shahidi S, Piroozi S. Comparison of the effects of transcutaneous electrical nerve stimulation and low-level laser therapy on drug-resistant temporomandibular disorders. J Dent (Shiraz). 2017;18(3):187-92.

Rastogi M, Khurana R, Revannasiddaiah S, Jaiswal I, Nanda SS, Gupta P, et al. Role of benzydamine hydrochloride in the prevention of oral mucositis inhead and neck cancer patients treated with radiotherapy (> 50 Gy) with orwithout chemotherapy. Support Care Cancer. 2017;25(5):1439-43.

Peterson DE, Srivastava R, Lalla RV. Oral mucosal injury in oncologypatients: perspectives on maturation of a field. Oral Dis. 2015;21(2):133-41.

Soares RG, Farias LC, Menezes ASS, Silva CSO, Tabosa ATL, Chagas PVF, et al. Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study. Lasers Med Sci. 2018;33(8):1813-9.

Santos RCS, Dias RS, Giordani AJ, Segretop RA, Segreto HRC. Mucosite em pacientes portadores de câncer de cabeça e pescoço submetidos à radioquimioterapia. Rev Esc Enferm USP. 2011;45(6):1338-44.

Antunes HS, Wajnberg G, Pinho MB, Jorge NAN, Moraes JLM, Stefanoff CG, et al. cDNA microarray analysis of human keratinocytes cells of patients submitted to chemoradiotherapy and oral photobiomodulation therapy: pilot study. Lasers Med Sci. 2018;33(1):11-18.

Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al., Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(9 Suppl):1995-2025.

Bockel S, Vallard A, Lévy A, Francois S, Bourdis M, Le Gallic C, et al. Pharmacological modulation of radiation-induced oral mucosal complications. Cancer Radiother. 2018;22(5):429-37.

World Health Organization. Handbook for Reporting Results of Cancer Treatment. Geneva, Switzerland: World Health Organization, 1979.

Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Guddattu V. Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial. J Photochem Photobiol B. 2015;144:51-6.

Kawashita Y, Koyama Y, Kurita H, Otsuru M, Ota Y, Okura M, et al. Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. Int J Oral Maxillofac Surg. 2019;(18)30419-3.

Bamps M, Dok R, Nuyts S. Low-level laser therapy stimulates proliferation in head and neck squamous cell carcinoma cells. Front Oncol. 2018;8:343.

Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453-61.

Lopes LD, Rodrigues AB, Brasil DRM, Moreira MMC, Amaral JG, Oliveira PP. Prevenção e tratamento da mucosite em ambulatório de oncologia: uma construção coletiva. Texto Contexto Enferm 2016;25(1):e2060014.

Bensadoun RJ. Photobiomodulation or low-level laser therapy in the management of cancer therapy-induced mucositis, dermatitis and lymphedema. Curr Opin Oncol. 2018;30(4):226-32.

Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Vadhiraja BM. Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients - a triple blinded randomized controlled trial. Radiother Oncol. 2012;104(3):349-54.

Silva VCR, Silveira FMM, Monteiro MGB, Cruz MMD, Caldas Júnior AF, Godoy GP. Photodynamic therapy for treatment of oral mucositis: pilot study with pediatric patients undergoing chemotherapy. Photodiagnosis Photodyn Ther. 2018;21:115-20.

Reolon LZ, Rigo L, Conto F, CÉ LC. Impacto da laserterapia na qualidade de vida de pacientes oncológicos portadores de mucosite oral. Rev Odontol. UNESP. 2017;46(1):19-27.

Brandão TB, Morais-Faria K, Ribeiro ACP, Rivera C, Salvajoli JV, Lopes MA, et al. Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses. Support Care Cancer. 2018;26(7):2417-23.

Campos L, Cruz ÉP, Pereira FS, Arana-Chavez VE, Simões A. Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters. J Biophotonics. 2016;9(11-12):1236-45.

Lopez TC, Martins MD, Pavesi VC, Ferreira LS, Bussadori SK, Moreira MS, et al. Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters. Braz Oral Res. 2013;27(4):342-8.

Thieme S, Ribeiro JT, Santos BG, Zieger RA, Severo MLB, Martins MAT. Comparison of photobiomodulation using either an intraoral or an extraoral laser on oral mucositis induced by chemotherapy in rats. Support Care Cancer. 2019.

González-Arriagada WA, Ramos LMA, Andrade MAC, Lopes MA. Efficacy of low-level laser therapy as an auxiliary tool for management of acute side effects of head and neck radiotherapy. J Cosmet Laser Ther. 2018;20(2):117-22.

Cavalcanti AL, Macêdo DJ, Dantas FSB, Menezes KS, Silva DFB, Junior WAM, Cavalcanti AFC. Evaluation of oral mucositis occurrence in oncologic patients under antineoplastic therapy submitted to the low-level laser coadjuvant therapy. J Clin Med. 2018;7(5). pii: E90.

Gobbo M, Verzegnassi F, Ronfani L, Zanon D, Melchionda F, Bagattoni S, et al. Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatr Blood Cancer. 2018;65(8):e27098.

Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, et al. Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial. Radiat Oncol. 2019;14(1):83.

Elad S, Arany P, Bensadoun RJ, Epstein JB, Barasch A, Raber-Durlacher J. Photobiomodulation therapy in the management of oral mucositis: search for the optimal clinical treatment parameters. Support Care Cancer. 2018;26(10):3319-321.

Guedes CCFV, de Freitas Filho SAJ, de Faria PR, Loyola AM, Sabino-Silva R, Cardoso SV. Variation of energy in photobiomodulation for the control of radiotherapy-induced oral mucositis: a clinical study in head and neck cancer patients. Int J Dent. 2018;2018:4579279.

He M, Zhang B, Shen N, Wu N, Sun J. A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients. Eur J Pediatr. 2018;177(1):7-17.

Medeiros-Filho JB, Maia Filho EM, Ferreira MC. Laser and photochemotherapy for the treatment of oral mucositis in young patients: randomized clinical trial. Photodiagnosis Photodyn Ther. 2017;18:39-45.

Pinheiro SL, Bonadiman AC, Lemos ALAB, Annicchino BM, Segatti B, Pucca DS, et al. photobiomodulation therapy in cancer patients with mucositis: a clinical evaluation. Photobiomodul Photomed Laser Surg. 2019;37(3):142-50.

Downloads

Publicado

2019-07-18

Como Citar

Lacerda-Santos, J. T., Fernandes Neto, J. de A., & Catão, M. H. C. de V. (2019). Fototerapia no tratamento da mucosite oral: uma revisão de literatura. Arquivos Em Odontologia, 55. https://doi.org/10.7308/aodontol/2019.55.e11

Edição

Seção

Artigos

Artigos mais lidos pelo mesmo(s) autor(es)