Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazil

  • Kamilla Menezes Oliveira Federal University of Bahia - UFBA
  • Lucas Magalhães Alcântara Federal University of Bahia - UFBA
  • Fernanda Gabriela Teixeira Federal University of Bahia - UFBA
  • Samir Andrade Mendonça Federal University of Bahia - UFBA
  • Djanilson Barbosa dos Santos Federal University of Bahia - UFBA
  • Lucas Miranda Marques Federal University of Bahia - UFBA
  • Maise Mendonça Amorim Federal University of Bahia - UFBA
  • Raquel de Souza Gestinari Federal University of Rio de Janeiro - UFRJ

Resumo

Aim: This study aimed to analyze the relationship between the polymorphism c.-889 C>T in the IL1A gene and periodontitis in subjects from Vitória da Conquista, Bahia, Brazil. Methods: Two hundred fifty-nine individuals were classified according to periodontitis diagnoses in cases and controls. Genomic DNA was extracted from buccal epithelial cells. Genotyping was performed by PCR-RFLP, followed by agarose gel electrophoresis. Data were analyzed using Chi-square, Fisher’s exact and Hosmer-Lemeshow tests. Results: In the individuals evaluated in this study, periodontitis was significantly associated with a low educational level (p = 0.024) and clinical variables, such as gingival bleeding (p = 0.019) and tooth mobility (p = 0.001). Among patients in the case group, the majority (72.88%) had a generalized form of periodontitis. The genotypic frequencies for IL1A c.–889 C>T between the case and control groups did not significantly differ (χ2 = 1.6983; p = 0.428). Conclusion: This study’s findings indicate the lack of association between periodontitis and the IL1A c -889 C>T gene polymorphism.
Uniterms: Peridontitis. Genetic polymorphism. Interleukin-1.

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Biografia do Autor

Kamilla Menezes Oliveira, Federal University of Bahia - UFBA

Laboratory of Cellular and Molecular Biology, Multidisciplinary Health Institute, Federal University of Bahia (UFBA), Vitória da Conquista, BA, Brazil.

Lucas Magalhães Alcântara, Federal University of Bahia - UFBA
Laboratory of Cellular and Molecular Biology, Multidisciplinary Health Institute, Federal University of Bahia (UFBA), Vitória da Conquista, BA, Brazil.
Fernanda Gabriela Teixeira, Federal University of Bahia - UFBA
Laboratory of Cellular and Molecular Biology, Multidisciplinary Health Institute, Federal University of Bahia (UFBA), Vitória da Conquista, BA, Brazil.
Samir Andrade Mendonça, Federal University of Bahia - UFBA
Laboratory of Cellular and Molecular Biology, Multidisciplinary Health Institute, Federal University of Bahia (UFBA), Vitória da Conquista, BA, Brazil.
Djanilson Barbosa dos Santos, Federal University of Bahia - UFBA
Health Sciences Center, UFBA Recôncavo, Santo Antonio de Jesus, BA, Brazil.
Lucas Miranda Marques, Federal University of Bahia - UFBA
Laboratory of Microbiology and Immunology, Multidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, BA, Brazil.
Maise Mendonça Amorim, Federal University of Bahia - UFBA
Laboratory of Cellular and Molecular Biology, Multidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, BA, Brazil.
Raquel de Souza Gestinari, Federal University of Rio de Janeiro - UFRJ
Núcleo em Ecologia e Desenvolvimento Socioambiental de Macaé (NUPEM), Federal University of Rio de Janeiro (UFRJ), Macaé, RJ, Brazil.

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Publicado
2016-06-15
Como Citar
Oliveira, K. M., Alcântara, L. M., Teixeira, F. G., Mendonça, S. A., dos Santos, D. B., Marques, L. M., Amorim, M. M., & Gestinari, R. de S. (2016). Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazil. Arquivos Em Odontologia, 51(4). Recuperado de https://periodicos.ufmg.br/index.php/arquivosemodontologia/article/view/3689
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