Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazi


  • Kamilla Menezes Oliveira Universidade Federal da Bahia
  • Lucas Magalhães Alcântara Universidade Federal da Bahia
  • Fernanda Gabriela Teixeira Universidade Federal da Bahia
  • Samir Andrade Mendonça Universidade Federal da Bahia
  • Djanilson Barbosa dos Santos Universidade Federal da Bahia
  • Lucas Miranda Marques Universidade Federal da Bahia
  • Maise Mendonça Amorim Universidade Federal da Bahia
  • Raquel de Souza Gestinari Universidade Federal do Rio de Janeiro



Aim: This study aimed to analyze the relationship between the polymorphism c.-889 C>T in the IL1A gene and periodontitis in subjects from Vitória da Conquista, Bahia, Brazil.

Methods: Two hundred fifty-nine individuals were classified according to periodontitis diagnoses in cases and controls. Genomic DNA was extracted from buccal epithelial cells. Genotyping was performed by PCR-RFLP, followed by agarose gel electrophoresis. Data were analyzed using Chi-square, Fisher’s exact and Hosmer-Lemeshow tests.

Results: In the individuals evaluated in this study, periodontitis was significantly associated with a low educational level (p = 0.024) and clinical variables, such as gingival bleeding (p = 0.019) and tooth mobility (p = 0.001). Among patients in the case group, the majority (72.88%) had a generalized form of periodontitis. The genotypic frequencies for IL1A c.–889 C>T between the case and control groups did not significantly differ (c2 = 1.6983; p = 0.428).

Conclusion: This study’s findings indicate the lack of association between periodontitis and the IL1A c -889 C>T gene polymorphism.


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How to Cite

Oliveira, K. M., Alcântara, L. M., Teixeira, F. G., Mendonça, S. A., Santos, D. B. dos, Marques, L. M., Amorim, M. M., & Gestinari, R. de S. (2016). Lack of association between IL1A c.-889 C>T gene polymorphism and chronic periodontitis in subjects from Bahia, Brazi. Arquivos Em Odontologia, 51(4).