Avaliação comparativa da citotoxicidade dos cimentos MTA Fillapex e AH Plus: revisão integrativa
Resumo
Objetivo: O objetivo deste estudo foi realizar uma revisão integrativa comparando a citotoxicidade dos cimentos MTA Fillapex e AH Plus aos tecidos periapicais. Métodos: Foram utilizados artigos na íntegra, nos idiomas português e inglês, publicados durante os períodos de 2010 a 2017, selecionados na base de dados Scielo e Pubmed, utilizando os seguintes descritores: AH Plus, MTA Fillapex e citotoxicidade. Foram excluídos, os trabalhos no idioma não inglês, artigos sem resumo, trabalhos realizados em dentes decíduos e casos clínicos. Resultados: Foram identificados dezenove artigos nas bases de dados, sendo dois artigos no SciELO e dezessete artigos no Pubmed. Após a leitura aprofundada desses artigos, foram excluídos seis artigos por não atenderem aos critérios de inclusão. Dessa forma, a amostra final foi composta por treze artigos científicos, todos de modelos experimentais, publicados em periódicos de procedência internacional, da área odontológica, sendo 50% dos estudos do ano de 2013. Conclusão: Os estudos demonstraram que o MTA Fillapex apresentou maior citotoxicidade aos tecidos periapicais que o cimento AH Plus. Descritores: Cimentos dentários. Sobrevivência celular. Teste de materiais. Materiais biocompatíveis.
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Referências
(1) Gil AC, Nakamura VC, Lopes RP, Lemos EM, Calil E, Amaral KF. Revisão contemporânea de obturação termoplastificada, valendo-se da técnica de compactação termomêcanica. Rev Saúde UNG Online. 2009;3(3): 20-9.
(2) Martins SC, Mello J, Martins CC, Maurício A, Gijeira A. Comparação da obturação en-dodôntica pelas técnicas de condensação lateral, híbrida de Tagger e Termafil: estudo piloto com micro-tomografia computadorizada. Rev Port Estomatol Med Dent Cir Maxilofac. 2011;52(2):59-69.
(3) Mayid BV, Doky CM. Obturacion con gutapecha termoplastificada. Publicacion Cientifica Facultad de Odontología UCR. 2010;12:73-80.
(4) Limkangwalmongkol S, Abbott PV, Sandler AB. Apical dye penetration with four root canal sealers and gutta-percha using longitudinal sectioning. J Endod. 1992 Nov;18(11):535-9.
(5) Yilmaz Z, Dogan AL, Ozdemir O, Serper A. Evaluation of the cytotoxicity of different root canal sealers on L929 cell line by MTT assay. Dent Mater J. 2012; 31(6):1028-32.
(6) Lopes HP, Siqueira JF. Endodontia: biologia e técnica. 2ª ed. Rio de Janeiro: Medsi; 2004.
(7) Leonardo MR, Flores DSH, Silva FWGP, Leonardo RT, Silva LAB. A comparison study of per-iapical repair in dogs’ teeth using Roeko Seal and AH Plus Root Canal Sealers: a histopatholog-ical evaluation. J Endod. 2008 Jul;34(7):822-5.
(8) Leonardo MR, Bezerra da Silva LA, Filho MT, Santana da Silva R. Release of formaldehyde by 4 endodontic sealers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Aug;88(2):221-5.
(9) Miletic I, Devcic N, Anic I, Borcic J, Karlovic Z, Osmak M. The cytotoxicity of RoekoSeal and AH plus compared during different setting periods. J Endod. 2005 Apr;31(4):307-9.
(10) Morgental RD, Vier-Pelisser FV, Oliveira SD, Antunes FC, Cogo DM, Kopper PM. Antibac-terial activity of two MTA-based root canal sealers. Int Endod J. 2011 Dec;44(12):1128-33.
(11) Silva EJNL, Rosa TP, Herrera DR, Jacinto RC, Gomes BPFA, Zaia AA. Evaluation of cytotoxi-city and physicochemical properties of calcium silicate-base endodontic sealer MTA Fillapex. J Endod. 2013 Feb;39(2):274-7.
(12) Nassri MRG, Lia RCC, Bombana AC. Análise da resposta tecidual de dois cimentos en-dodonticos. J Appl Oral Sci. 2003;11(1):9-14.
(13) Bin CV, Valera MC, Camargo SE, Rabelo SB, Silva GO, Balducci I, et al. Cytotoxicity and genoxicity of root canal sealers based on mineral trioxide aggregate. J Endod. 2012 Apr;38(4):495-500.
(14) Silva EJNL, Santos CS, Zaia AA. Long-term cytotoxic effects of contemporary root canal sealers. J Appl Oral Sci. 2013 Jan-Feb;21(1):43-7.
(15) Pamukçu GE, Yalvaç ME, Kayahan MB, Sunay H, Sahin F, Bayirli G. Human tooth germ stem cell response to calcium-silicate based endodontic cements. J Appl Oral Sci. 2013 Jul-Aug;21(4):351-7.
(16) Zhou HM, Du TF, Shen Y, Wang ZJ, Zheng YF, Haapasalo M. In vitro cytotoxicity of calcium silicate-cantaining endodontic sealers. J Endod. 2015 Jan;41(1):56-61.
(17) Silva EJNL, Zaia AA, Peters OA. Cytocompatibility of calcium silicate-based sealers in a three dimensional cell culture model. Clin Oral Investig. 2017 Jun;21(5):1531-6.
(18) Gandolfi MG, Prati C. MTA and F-doped MTA cements used as sealers with warm gutta-pecha. Long-term study of sealing ability. Int Endod J. 2010 Oct;43(10):889-901.
(19) Accardo CH, Himel VT, Lallier TE. A novel GuttaFlow sealer supports cell survivaland at-tachement. J Endod. 2014 Feb;40(2):231-4.
(20) Chang SW, Lee SY, Kang SK, Kum KY, Kim EC. In vitro biocompatibility, inflammatory re-sponse, and osteogenic potential of 4 root canal sealers: Sealapex, Sankin, Apatite Root Seal-er, MTA Fillapex, and iRoot SP root canal sealer. J Endod. 2014 Oct;40(10):1642-8.
(21) Borges RP, Sousa-Neto MD, Versiani MA, Rached-Junior FA, De-Deus G, Miranda CE, et al. Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test. Int Endod J. 2012 May;45(5):419-28.
(22) Karapinar-Kazandag M, Bayrak OF, Yalvac ME, Ersev H, Tanalp J, Sahin F, et al. Cytotoxici-ty of 5 endodontic sealers on L929 cell line and human dental pulp cells. Int Endod J. 2011 Jul;44(7):626-34.
(23) Merdad K, Pascon AE, Kulkarni G, Santerre P, Friedman S. Short-term cytotoxicity as-sessment of components of the epiphany resin-percha obturating system by indirect and direct contact Millipore filter assays. J Endod. 2007 Jan;33(1):24-7.
(24) Eldeniz AU, Mustafa K, Orstavik D, Dahl JE. Cytotoxicity of new resin-, calcium hydroxide- and silicone-based root canal sealers on fibroblasts derived from human gingiva and L929 cell lines. Int Endod J. 2007 May;40(5):329-37
(25) Cohen BI, Pagnillo MK, Musikant BL, Deutsch AS. An in vitro study of the cytotoxicity of two root canal sealers. J Endod. 2000 Apr;26(4):228-9.
(26) Silva EJ, Perez R, Valentim RM, Belladonna FG, De-Deus GA, Lima IC, et al. Dissolution, dislocation and dimensional changes of endodontic sealers after a solubility challenge: a mi-cro-CT approach. Int Endod J. 2017 Apr;50(4):407-14.
(27) Saygili G, Saygili S, Tuglu I, Capar ID. In vitro cytotoxicity of GutaFlow Bioseal, GutaFlow2, AH Plus and MTA Fillapex. Iran Endod J. 2017 Summer;12(3):354-9.
(28) Collado-González M, Tomás-Catalá CJ, Onate-Sánchez RE, Moraleda JM, Rodríguez-Loano FJ. Cytotoxicity of GutaFlow Bioseal, GutaFlow2, MTA Fillapex and AH Plus on human periodontal ligament stem cells. J Endod. 2017 May;43(5):816-22.
(29) Poggio C, Riva P, Chiesa M, Colombo M, Pietrocola G. Comparative cytotoxicity evalua-tion of eight root canal sealers. J Clin Exp Dent. 2017 Apr; 9(4):574–8.
(30) Szczurko G, Pawinska M, Luczaj-Cepowicz E, Kierklo A, MArczuk-Kolada G, Holownia A. Effect of root canal sealers on human periodontal ligament fibroblast viability: ex vivo study. Odontology. 2017 Dec 14.
(31) Silva EJ, Accors-Mendonça T, Pedrosa AC, Granjeiro JM, Zaia AA. Long- Term cytotoxicity, pH and dissolution rate of AH Plus and MTA Fillapex. Braz Dent J. 2016 Jul-Aug;27(4):419-23.
(32) Victoria-Escandell A, Ibanez-Cabellos JS, Cutanda SBS, Pascual EB, Garcia JB, Lopez EG, et al. Cellular response in human dental pulp stem cells treated with three endodontic materi-als. Stem Cells Int. 2017;2017:8920356.
(33) Teixeira L, Basso FG, Hebling J, Costa CAS, Mori GG, Silva-Sousa YTC, et al. Cytotoxicity evaluation of root canal sealers using an in vitro experimental model with roots. Braz Dent J. 2017 Mar-Apr;28(2):165-71.
(2) Martins SC, Mello J, Martins CC, Maurício A, Gijeira A. Comparação da obturação en-dodôntica pelas técnicas de condensação lateral, híbrida de Tagger e Termafil: estudo piloto com micro-tomografia computadorizada. Rev Port Estomatol Med Dent Cir Maxilofac. 2011;52(2):59-69.
(3) Mayid BV, Doky CM. Obturacion con gutapecha termoplastificada. Publicacion Cientifica Facultad de Odontología UCR. 2010;12:73-80.
(4) Limkangwalmongkol S, Abbott PV, Sandler AB. Apical dye penetration with four root canal sealers and gutta-percha using longitudinal sectioning. J Endod. 1992 Nov;18(11):535-9.
(5) Yilmaz Z, Dogan AL, Ozdemir O, Serper A. Evaluation of the cytotoxicity of different root canal sealers on L929 cell line by MTT assay. Dent Mater J. 2012; 31(6):1028-32.
(6) Lopes HP, Siqueira JF. Endodontia: biologia e técnica. 2ª ed. Rio de Janeiro: Medsi; 2004.
(7) Leonardo MR, Flores DSH, Silva FWGP, Leonardo RT, Silva LAB. A comparison study of per-iapical repair in dogs’ teeth using Roeko Seal and AH Plus Root Canal Sealers: a histopatholog-ical evaluation. J Endod. 2008 Jul;34(7):822-5.
(8) Leonardo MR, Bezerra da Silva LA, Filho MT, Santana da Silva R. Release of formaldehyde by 4 endodontic sealers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Aug;88(2):221-5.
(9) Miletic I, Devcic N, Anic I, Borcic J, Karlovic Z, Osmak M. The cytotoxicity of RoekoSeal and AH plus compared during different setting periods. J Endod. 2005 Apr;31(4):307-9.
(10) Morgental RD, Vier-Pelisser FV, Oliveira SD, Antunes FC, Cogo DM, Kopper PM. Antibac-terial activity of two MTA-based root canal sealers. Int Endod J. 2011 Dec;44(12):1128-33.
(11) Silva EJNL, Rosa TP, Herrera DR, Jacinto RC, Gomes BPFA, Zaia AA. Evaluation of cytotoxi-city and physicochemical properties of calcium silicate-base endodontic sealer MTA Fillapex. J Endod. 2013 Feb;39(2):274-7.
(12) Nassri MRG, Lia RCC, Bombana AC. Análise da resposta tecidual de dois cimentos en-dodonticos. J Appl Oral Sci. 2003;11(1):9-14.
(13) Bin CV, Valera MC, Camargo SE, Rabelo SB, Silva GO, Balducci I, et al. Cytotoxicity and genoxicity of root canal sealers based on mineral trioxide aggregate. J Endod. 2012 Apr;38(4):495-500.
(14) Silva EJNL, Santos CS, Zaia AA. Long-term cytotoxic effects of contemporary root canal sealers. J Appl Oral Sci. 2013 Jan-Feb;21(1):43-7.
(15) Pamukçu GE, Yalvaç ME, Kayahan MB, Sunay H, Sahin F, Bayirli G. Human tooth germ stem cell response to calcium-silicate based endodontic cements. J Appl Oral Sci. 2013 Jul-Aug;21(4):351-7.
(16) Zhou HM, Du TF, Shen Y, Wang ZJ, Zheng YF, Haapasalo M. In vitro cytotoxicity of calcium silicate-cantaining endodontic sealers. J Endod. 2015 Jan;41(1):56-61.
(17) Silva EJNL, Zaia AA, Peters OA. Cytocompatibility of calcium silicate-based sealers in a three dimensional cell culture model. Clin Oral Investig. 2017 Jun;21(5):1531-6.
(18) Gandolfi MG, Prati C. MTA and F-doped MTA cements used as sealers with warm gutta-pecha. Long-term study of sealing ability. Int Endod J. 2010 Oct;43(10):889-901.
(19) Accardo CH, Himel VT, Lallier TE. A novel GuttaFlow sealer supports cell survivaland at-tachement. J Endod. 2014 Feb;40(2):231-4.
(20) Chang SW, Lee SY, Kang SK, Kum KY, Kim EC. In vitro biocompatibility, inflammatory re-sponse, and osteogenic potential of 4 root canal sealers: Sealapex, Sankin, Apatite Root Seal-er, MTA Fillapex, and iRoot SP root canal sealer. J Endod. 2014 Oct;40(10):1642-8.
(21) Borges RP, Sousa-Neto MD, Versiani MA, Rached-Junior FA, De-Deus G, Miranda CE, et al. Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test. Int Endod J. 2012 May;45(5):419-28.
(22) Karapinar-Kazandag M, Bayrak OF, Yalvac ME, Ersev H, Tanalp J, Sahin F, et al. Cytotoxici-ty of 5 endodontic sealers on L929 cell line and human dental pulp cells. Int Endod J. 2011 Jul;44(7):626-34.
(23) Merdad K, Pascon AE, Kulkarni G, Santerre P, Friedman S. Short-term cytotoxicity as-sessment of components of the epiphany resin-percha obturating system by indirect and direct contact Millipore filter assays. J Endod. 2007 Jan;33(1):24-7.
(24) Eldeniz AU, Mustafa K, Orstavik D, Dahl JE. Cytotoxicity of new resin-, calcium hydroxide- and silicone-based root canal sealers on fibroblasts derived from human gingiva and L929 cell lines. Int Endod J. 2007 May;40(5):329-37
(25) Cohen BI, Pagnillo MK, Musikant BL, Deutsch AS. An in vitro study of the cytotoxicity of two root canal sealers. J Endod. 2000 Apr;26(4):228-9.
(26) Silva EJ, Perez R, Valentim RM, Belladonna FG, De-Deus GA, Lima IC, et al. Dissolution, dislocation and dimensional changes of endodontic sealers after a solubility challenge: a mi-cro-CT approach. Int Endod J. 2017 Apr;50(4):407-14.
(27) Saygili G, Saygili S, Tuglu I, Capar ID. In vitro cytotoxicity of GutaFlow Bioseal, GutaFlow2, AH Plus and MTA Fillapex. Iran Endod J. 2017 Summer;12(3):354-9.
(28) Collado-González M, Tomás-Catalá CJ, Onate-Sánchez RE, Moraleda JM, Rodríguez-Loano FJ. Cytotoxicity of GutaFlow Bioseal, GutaFlow2, MTA Fillapex and AH Plus on human periodontal ligament stem cells. J Endod. 2017 May;43(5):816-22.
(29) Poggio C, Riva P, Chiesa M, Colombo M, Pietrocola G. Comparative cytotoxicity evalua-tion of eight root canal sealers. J Clin Exp Dent. 2017 Apr; 9(4):574–8.
(30) Szczurko G, Pawinska M, Luczaj-Cepowicz E, Kierklo A, MArczuk-Kolada G, Holownia A. Effect of root canal sealers on human periodontal ligament fibroblast viability: ex vivo study. Odontology. 2017 Dec 14.
(31) Silva EJ, Accors-Mendonça T, Pedrosa AC, Granjeiro JM, Zaia AA. Long- Term cytotoxicity, pH and dissolution rate of AH Plus and MTA Fillapex. Braz Dent J. 2016 Jul-Aug;27(4):419-23.
(32) Victoria-Escandell A, Ibanez-Cabellos JS, Cutanda SBS, Pascual EB, Garcia JB, Lopez EG, et al. Cellular response in human dental pulp stem cells treated with three endodontic materi-als. Stem Cells Int. 2017;2017:8920356.
(33) Teixeira L, Basso FG, Hebling J, Costa CAS, Mori GG, Silva-Sousa YTC, et al. Cytotoxicity evaluation of root canal sealers using an in vitro experimental model with roots. Braz Dent J. 2017 Mar-Apr;28(2):165-71.
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Marinho, J. C. S., Cunha, L. de A., Lacerda, M. F. L. S., Lacerda, G. P., Coelho, R. G., & Girelli, C. F. M. (2017). Avaliação comparativa da citotoxicidade dos cimentos MTA Fillapex e AH Plus: revisão integrativa. Arquivos Em Odontologia, 53. Recuperado de https://periodicos.ufmg.br/index.php/arquivosemodontologia/article/view/3715
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