Beneficial effects of three natural products for the treatment of denture stomatitis

a randomized clinical trial


  • Paulo Maurício Batista da Silva Aeronautical Hospital Belem
  • Ana Paula Chappuis Chocano University of São Paulo
  • Helena Sandrini Venante University of São Paulo
  • Rodrigo Moreira Bringel da Costa University of São Paulo
  • Rafaela Alves da Silva University of São Paulo
  • Karin Hermana Neppelenbroek University of São Paulo
  • Vanessa Soares Lara University of São Paulo
  • Vinícius Carvalho Porto University of São Paulo



Aim: To evaluate the effect of three natural antifungal agents combined with routine denture care on the treatment of DS, using a quantitative mycological culture analysis.

Methods: Thirty denture wearers with denture stomatitis DS were treated using five substances: sterile distilled water (G1), nystatin oral suspension (G2), 20% alcoholic extract propolis (G3), Punica granatum Linné gel (G4), and Uncaria tomentosa gel (G5). The substances were used 3 times a day for 14 days. Quantitative mycological culture analysis of samples collected from the palatal mucosa was performed at three stages: before treatment (T0), after 14 days of treatment (T1), and 30 days after treatment completion (T2). Data were evaluated using Kruskal-Wallis and Friedman tests (p < 0.05).

Results: Palatal mucosa intragroup analysis showed a significant reduction of Candida CFU/mL values for all groups at T1 compared to T0 (p < 0.05). However, they did not present statistical differences when comparing T1 and T2 (p > 0.05). The intergroup analysis demonstrated that there are no statistical differences, regardless of the evaluation time (p > 0.05).

Conclusion: The natural products tested showed a satisfactory result on DS treatment, which proved to be equivalent to conventional topical therapy with nystatin and to treatment using only regular oral hygiene procedures.

Uniterms: Stomatitis, denture. Candida albicans. Biological products. Colony count. Antifungal agents.


Não há dados estatísticos.


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Como Citar

da Silva, P. M. B. ., Chocano, A. P. C. ., Venante, H. S. ., da Costa, R. M. B. ., da Silva, R. A. ., Neppelenbroek, K. H. ., Lara, V. S. ., & Porto, V. C. (2021). Beneficial effects of three natural products for the treatment of denture stomatitis : a randomized clinical trial. Arquivos Em Odontologia, 57, 141–148.




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