Conduta Interdisciplinar para tratar paciente com Angiossarcoma Epitelióide

relato de um caso-clínico


  • Raquel Teodoro Santos Teixeira São Paulo State University
  • Henrique Zanoni Fernandes São Paulo State University
  • Haglay Palandi de Oliveira Belloti São Paulo State University
  • Maria das Graças Vilela Goulart São Paulo State University
  • Mônica Fernandes Gomes São Paulo State University


Angiossarcoma epitelióide, Quimioterapia, Saúde bucal


Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. The present study aims to describe the radiological, clinicopathological, and immunohistochemical findings of a case of epithelioid angiosarcoma located in the posterior mediastinum of a 65-year-old male patient who underwent surgery and clinical treatment (Doxorubicin-based chemoterapy). It could be observed that the patient presented poor oral hygiene, severe cervical erosions in his teeth, chronic caries, periodontal disease, and periapical abscess. For this reason, the participation of a dentist in an interdisciplinary team is of utmost importance. Oral support treatment also becomes essential in an attempt to eliminate all foci of oral infections, as well as minimize morbidity and improve the general condition of the patient before, during, and after oncological treatment. In addition, the dentist will work toward the education and motivation of the patient to take on an appropriate oral hygiene so as to minimize the oral complications of chemotherapy, in turn providing better conditions for the patient to eat, speak, socialize, and maintain a high quality of life.


Não há dados estatísticos.


Mentzel T, Katenkamp D. Intraneural angiosarcoma and angiorsarcoma arising in benign and malignant peripheral nerve sheath tumours: clinicopathological and immunohistochemical analysis of four cases. Histopathology. 1999; 35:114-20.

Roh MS, Seo JY, Hong SH. Epithelioid angiosarcoma of the pleura: a case report. J Korean Med Sci. 2001; 16:792-5.

Triantafillidou K, Lazaridis N, Zaramboukas T. Epithelioid angiosarcoma of the maxillary sinus and the maxilla: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94:333-7.

Deshpande V, Rosenberg AE, O’Connell JX, Nielsen GP. Epithelioid angiosarcoma of the bone: a series of 10 cases. Am J Surg Pathol. 2003; 27:709-16.

López L, Iriberri M, Cancelo L, Gómez A, Uresandi F, Atxotegui V. Persistent hemoptysis secondary to extensive epithelioid angiosarcoma. Arch Bronconeumol. 2004, 40:188-90.

Macías-Martínez V, Murrieta-Tiburcio L, Molina-Cárdenas H, Domínquez-Malagón H. Epithelioid angiosarcoma of the breast: clinicopathological, immunohistochemical, and ultrastructural study of a case. Am J Surg Pathol. 1997; 21:599-604.

Wehrli BM, Janzen DL, Shokeir O, Masri BA, Byrne SK, O’Connell JX. Epithelioid angiosarcoma arising in a surgically constructed arteriovenous fistula: a rare complication of chronic immunosuppression in the setting of renal transplantation. Am J Surg Pathol. 1998; 22:1154-9.

Refre GR, Buenconcejo LS, Aleta KNR, Tan- Liu NS, Wang AD. Breast mass in a male patient: a case of primary thoracic epithelioid angiosarcoma. Philipp J Intern Med. 2006; 44:197-203.

Rosemberg SW. Oral complications of cancer chemotherapy: a review of 398 patients. J Oral Med. 1986; 41:93-7.

Massler Jr CF. Preventing and treating oral complications of cancer therapy. Gen Dent. 2000; 48:652-5.

Sonis ST, Fey EG. Oral complications of cancer therapy. Oncology. 2002; 16:680-95.

Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol. 2003; 39:91-100.

McGuire DB. Barriers and strategies in implementation of oral care standards for cancer patients. Support Care Cancer. 2003; 11:435-41.

Redding SW. Oral complications of cancer therapy. Tex Med. 2003; 99:54-7.

Sadler GR, Stoudt A, Fullerton JT, Oberle- Edwards LK, Nguyen Q, Epstein JB. Managing the oral sequelae of cancer therapy. Medsurg Nurs. 2003; 12:28-36.

Gomes MF, Kohlemann KR, Plens G, Silva MM, Pontes EM, Rocha JC. Oral manifestations during chemotherapy for acute lymphoblastic leukemia: a case report. Quintessence Int. 2005; 36:307-13.

Teltzrow T, Hallermann C, Muller S, Schwipper V. Foreign body-induced angiosarcoma 60 years after a shell splinter injury. Mund Kiefer Gesichtschir. 2006; 10:415-8.

El-Bayoumy K, Chung FL, Richie J, et al. Dietary control of cancer. Proc Soc Exp Biol Med. 1997; 216:211-23.

Pinto BM, Trunzo JJ. Health behaviors during and after a cancer diagnosis. Cancer. 2005; 104:2614-23. Errata em: Cancer. 2006; 106:1641.

Hashimoto Y, Skacel M, Adams JC. Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol. 2005; 37:1787-804.

Yoder BJ, Tso E, Skacel M, et al. The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor- negative breast cancer and a more aggressive clinical course. Clin Cancer Res. 2005; 11:186- 92.

Silverman S. Oral cancer: complications of therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 88:122-6.

Martindale. The complete drug reference. 33nded. London: The Pharmaceutical Press; 2002.

Kilickap S, Barista I, Akgul E, Aytemir K, Aksoy A, Tekuzman G. Early and late arrhythmogenic effects of doxorubicin. South Med J. 2007; 100:262-5.

Sonis ST. Oral mucositis in cancer therapy. J Support Oncol. 2004; 2:3-8.

Raut A, Huryn JM, Hwang, FR, Zlotolow, IM. Sequelae and complications related to dental extractions in patients with hematologic malignancies and the impact on medical outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92:49-55.

Coleman S. An overview of oral complications of adult patients with malignant haematological conditions who have undergone radiotherapy or chemotherapy. J Adv Nurs. 1995; 22:1085-91.

Branchi R, Fancelli V, Durval E, De Salvador A. The patient with xerostomia: medical therapy, prosthetic therapy. Minerva Stomatol. 2003; 52:455-63.

Friedlander AH, Friedlande IK, Gallas M, Velasco E. Late-life depression: its oral health significance. Int Dent J. 2003; 53:41-50.




Como Citar

Teixeira, R. T. S., Fernandes, H. Z., Belloti, H. P. de O., Goulart, M. das G. V., & Gomes, M. F. (2016). Conduta Interdisciplinar para tratar paciente com Angiossarcoma Epitelióide: relato de um caso-clínico. Arquivos Em Odontologia, 46(3). Recuperado de