Head and neck malignant tumors in childhood

narrative literature review

Authors

  • Rebeca Tavares Freitas Escola Bahiana de Medicina e Saúde Pública
  • Marlene Xavier de Andrade Damasceno Faculdade Adventista da Bahia
  • Michele Rosas Couto Costa Faculdade Adventista da Bahia
  • Illa Oliveira Bitencourt Farias Escola Bahiana de Medicina e Saúde Pública
  • Alena Ribeiro Alves Peixoto Medrado Escola Bahiana de Medicina e Saúde Pública
  • Juliana Borges de Lima Dantas Escola Bahiana de Medicina e Saúde Pública / Faculdade Adventista da Bahia

DOI:

https://doi.org/10.35699/2178-1990.2023.47940

Keywords:

Neoplasms, Child, Adolescent

Abstract

Aim: To verify the clinicohistopathological characteristics of the most common malignant tumors in the head and neck region in children and adolescents, as well as their respective treatments and prognosis.

Methods: This was a narrative literature review. The platforms Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Electronic Library Online (SCIELO), and PubMed were used, through the cross-referencing of DeCS/MeSH descriptors with Boolean operators, in addition to secondary free search. After all refinement steps, a total of 34 articles were included.

Results: Despite malignant tumors being relatively rare in the pediatric population, they represent a high mortality rate in childhood in Brazil. The most common types of cancer in the head and neck are: mucoepidermoid carcinoma, acinar cell carcinoma and squamous cell carcinoma (SCC) and osteosarcoma, as well rhabdomyosarcoma and acinar cell carcinoma. The parotid gland is the most affected by gland tumors in childhood. Rhabdomyosarcoma is the most common cancer of muscle cells in children and adolescents, and SCC is less common neoplasm in this population, which can be aggressive and have an unfavorable prognosis, as well as osteosarcoma. The treatment is multimodal due to the behavioral differences of these neoplasms.

Conclusion: Despite head and neck cancer being a rare condition in the pediatric population, knowledge about the clinical and histopathological characteristics can facilitate immediate diagnosis and early treatment.

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References

Fernandes SSM. Linfoma de Hodgkin na infância: relato de caso e revisão da literatura [dissertação]. São Paulo: Hospital do Servidor Público Municipal; 2011.

Gurgel BCMS, Leonel ACLS, Perez DEC, Castro JFL, Carvalho EJA. Neoplasias orofaciais em crianças e adolescentes. Arq. Odontol. 2020;56:1-9.

Melo AUC, Valente ROH, Martorelli SBF, Ribeiro CF, Rosa MRD. Prevalence of malignant tumors of the head and neck region in infant and juvenile patients. Pesqui Bras Odontopediatria Clin Integr. 2010;10(3):493-8.

Wani V, Kulkarni A, Pustake B, Takate V, Wani P, Sondhi JS. Prevalence, complications and dental management of the oral cancer in the pediatric patients. J Cancer Res Ther. 2018;14(6):1407-11.

Citak EC, Yilmaz EB, Sagcan F, Bozkurt F, Arpaci RB, Vayisoglu Y. Mucoepidermoid carcinoma in warthin tumor of the parotis in childhood: a case report and review of the literature. J Pediatr Hematol Oncol. 2019;41(6):494-7.

Sato T, Kamata SE, Kawabata K, Nigauri T, Mitani H, Beppu T et al. Acinic cell carcinoma of the parotid gland in a child. Pediatr Surg Int. 2005;21(5):377-80.

Skálová A, Hyrcza MD, Leivo I. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: salivary glands. Head Neck Pathol. 2022;16(1):40-53.

Córdoba Rovira SM, Inarejos Clemente EJ. Childhood rhabdomyosarcoma. Radiologia. 2016;58(6):481-90.

Moretti G, Guimarães R, Oliveira KM, Sanjar F, Voegels RL. Rabdomiossarcoma de cabeça e pescoço: 24 casos e revisão da literatura. Braz J Otorhinolaryngol. 2010;76(4):333-7.

Vered M, Wright JM. Update of the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2022;16(1):63-75.

Stolk-Liefferink SAH, Dumans AG, van der Meij EH, Knegt PP, van der Wal KGH. Oral squamous cell carcinoma in children; review of an unusual entity. Int J Pediatr Otorhinolaryngol. 2008;72(1):127-31.

Badoual C. Update of the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: oropharynx and nasopharynx. Head Neck Pathol. 2022;16(1)19-30.

Muller S, Tilakaratne WM. Update of the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: tumors of the oral cavity and mobile tongue. Head Neck Pathol. 2022;16(1):54-62.

Lemos Junior CA, Alves FA, Torres-Pereira CC, Biazevic MGH, Pinto Júnior DS, Nunes FD. Câncer de boca baseado em evidências científicas. Rev Assoc Paul Cir Dent. 2013;67(3):178-86.

Myers JN, Elkins T, Roberts D, Byers RM. Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg. 2000;122(1):44-51.

Frare JC, Sawazaki-Calone I, Ayroza-Rangel ALC, Bueno AG, Morais CF, Nagai HM, et al. Histopathological grading systems analysis of oral squamous cell carcinomas of young patients. Med Oral Patol Oral Cir Bucal. 2016;21(3):e285-98.

Claude L, Jouglar E, Duverge L, Orbach D. Update in pediatric nasopharyngeal undifferentiated carcinoma. Br J Radiol. 2019;92(1102).

Rouge MÈ, Brisse H, Helfre S, Teissier N, Freneaux P, Orbach D. Le carcinome indifférencié du nasopharynx de l’enfant et de l’adolescent. Bull Cancer. 2011;98(3):337-45.

Martins BG, Guedes CCFV. Osteossarcoma oral: uma revisão da literatura. Res Soc Dev. 2022;11(14):1-8.

Gonçalo RIC, Medeiros CKS, Chaves Neto HP, Santos JLM, Germano AR, Queiroz LMG. Large-extension osteosarcoma with involvement of multiple maxillofacial structures: a rare case report. Res Soc Dev. 2020;9(10):1-11.

Cavalcante IF. Mecanismos genéticos do osteossarcoma para a elucidação de novos alvos terapêuticos [dissertação]. Brasília: Centro Universitário de Brasília; 2021.

Feriani GG, Venâncio GSB, Falquer LVF, Gomes AOF, Oliveira SP, Buexm LA. Mandibular postirradiation osteosarcoma: clinical case report. J Oral Cancer Res. 2020;3(2):40-3.

Jesus GS. Quimioterapia como tratamento de osteossarcomas maxilofaciais: revisão de literatura [dissertação]. Salvador (BA): Escola Bahiana de Medicina e Saúde Pública; 2020.

Gomes AM, Lima TMNR, Bezerra PMM, Serpa EBM, Vieira TI, Cavalcanti YW, et al. Custo-efetividade de tratamento para o osteossarcoma em pacientes infantojuvenis. Res Soc Dev. 2022;11(4):1-10.

Santana CS, Macedo EC, Alves AMA, Almeida UL.Repercussão do diagnóstico de leucemia ao paciente infantojuvenil e seu familiar: revisão integrativa. Res Soc Dev. 2022;11(6):1-9.

Santos JS, Sá LFP, Mata JPO, Teixeira AS, Crisanto AVSMS, Amorim GR et al. Diagnóstico da leucemia linfoblástica aguda em crianças. Res Soc Dev. 2022;11(9):1-6.

Santos JCO, Santos DKC, Fonseca LS, Ferreira LLL, Carvalho BC, Kameo SY. Leucemia em crianças e adolescentes: implicações do diagnóstico e assistência em saúde no núcleo familiar. Arq Ciênc Saúde. 2022;29(1):36-40.

Hunhoff BL, Luckmann L, Lima IAB. Manifestações orais em pacientes oncológicos pediátricos: revisao de literatura. Res Soc Dev. 2022;11(15):1-20.

Bueno JVM, Bueno ACM, Moraes Filho PEM, Costa LEA, Costa JVA, Almeida PPAC et al. O diagnóstico precoce em pacientes portadores de linfoma de hodgkin e não hodgkin: uma revisão de literatura. REASE. 2023;9(5):1035-45.

Luiz BS, Provazzi PJS. Manifestações bucais em pacientes oncológicos pediátricos submetidos à quimioterapia: uma revisão narrativa de literatura. Revista Interciência: IMES Catanduva. 2022;1(10):51-61.

Karhana AN, Varan A, Akyüz C, Aydin B, Yalçin B, Kutluk T et al. Desenlace de 102 pacientes con linfoma de Hodgkin menores de 5 años. Arch Argent Pediatr. 2019;117(5):e459-65.

Gómez-Almaguer D, González-Llano O, Jiménez-Antolinez V, Gómez-De León A. Treatment of classical Hodgkin’s lymphoma in children and adolescents. Expert Opin Pharmacother. 2019;20(10):1227-34.

Marques APC, Sena ACV, Drummond Júnior DG, Santana EF, Rodrigues JAC, Bravo Filho JDP et al. Taxa de sobrevida em pacientes pediátricos com linfoma não hodgkin e fatores prognósticos: revisão da literatura. Braz J Health Rev. 2021;4(5):22543-22556.

Ferry JA. Update of the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: hematolymphoid proliferations and neoplasms. Head Neck Pathol. 2022;16(1):101-9.

Published

2024-01-22

How to Cite

Freitas, R. T., Damasceno, M. X. de A., Costa, M. R. C., Farias, I. O. B., Medrado, A. R. A. P., & Dantas, J. B. de L. (2024). Head and neck malignant tumors in childhood: narrative literature review. Arquivos Em Odontologia, 59, 273–282. https://doi.org/10.35699/2178-1990.2023.47940

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