Interdisciplinary approach to treating patients with Epithelioid Angiosarcoma
a case report
Keywords:
Epithelioid angiosarcoma, Drug therapy, Oral healthAbstract
Angiossarcoma epitelióide é uma neoplasia maligna rara das células vasculares endoteliais. Neste estudo, foram descritos os achados radiológicos, clinicopatológicos e imunohistoquímicos de um caso de angiossarcoma epitelióide no mediastino posterior, em um paciente de 65 anos de idade, submetido à cirurgia e tratamento clínico (quimioterapia com Doxorubicina). Observou-se que o paciente apresentava higiene bucal precária, erosões cervicais severas, lesões de cárie crônicas, doença periodontal e abscesso periapical. A participação do dentista em uma equipe multidisciplinar é muito importante. O tratamento de suporte é essencial para eliminar todos os focos de infecção oral, minimizar a morbidade e melhorar as condições gerais do paciente antes, durante e após o tratamento oncológico. Além disso, é importante que o dentista trabalhe na educação e motivação do paciente para conseguir uma adequada higienização bucal e para tentar minimizar as complicações orais da quimioterapia, melhorando as condições para que o paciente se alimente, fale e socialize-se, tendo uma melhor qualidade de vida.
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References
Mentzel T, Katenkamp D. Intraneural angiosarcoma and angiorsarcoma arising in benign and malignant peripheral nerve sheath tumours: clinicopathological and immunohistochemical analysis of four cases. Histopathology. 1999; 35:114-20.
Roh MS, Seo JY, Hong SH. Epithelioid angiosarcoma of the pleura: a case report. J Korean Med Sci. 2001; 16:792-5.
Triantafillidou K, Lazaridis N, Zaramboukas T. Epithelioid angiosarcoma of the maxillary sinus and the maxilla: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94:333-7.
Deshpande V, Rosenberg AE, O’Connell JX, Nielsen GP. Epithelioid angiosarcoma of the bone: a series of 10 cases. Am J Surg Pathol. 2003; 27:709-16.
López L, Iriberri M, Cancelo L, Gómez A, Uresandi F, Atxotegui V. Persistent hemoptysis secondary to extensive epithelioid angiosarcoma. Arch Bronconeumol. 2004, 40:188-90.
Macías-Martínez V, Murrieta-Tiburcio L, Molina-Cárdenas H, Domínquez-Malagón H. Epithelioid angiosarcoma of the breast: clinicopathological, immunohistochemical, and ultrastructural study of a case. Am J Surg Pathol. 1997; 21:599-604.
Wehrli BM, Janzen DL, Shokeir O, Masri BA, Byrne SK, O’Connell JX. Epithelioid angiosarcoma arising in a surgically constructed arteriovenous fistula: a rare complication of chronic immunosuppression in the setting of renal transplantation. Am J Surg Pathol. 1998; 22:1154-9.
Refre GR, Buenconcejo LS, Aleta KNR, Tan- Liu NS, Wang AD. Breast mass in a male patient: a case of primary thoracic epithelioid angiosarcoma. Philipp J Intern Med. 2006; 44:197-203.
Rosemberg SW. Oral complications of cancer chemotherapy: a review of 398 patients. J Oral Med. 1986; 41:93-7.
Massler Jr CF. Preventing and treating oral complications of cancer therapy. Gen Dent. 2000; 48:652-5.
Sonis ST, Fey EG. Oral complications of cancer therapy. Oncology. 2002; 16:680-95.
Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol. 2003; 39:91-100.
McGuire DB. Barriers and strategies in implementation of oral care standards for cancer patients. Support Care Cancer. 2003; 11:435-41.
Redding SW. Oral complications of cancer therapy. Tex Med. 2003; 99:54-7.
Sadler GR, Stoudt A, Fullerton JT, Oberle- Edwards LK, Nguyen Q, Epstein JB. Managing the oral sequelae of cancer therapy. Medsurg Nurs. 2003; 12:28-36.
Gomes MF, Kohlemann KR, Plens G, Silva MM, Pontes EM, Rocha JC. Oral manifestations during chemotherapy for acute lymphoblastic leukemia: a case report. Quintessence Int. 2005; 36:307-13.
Teltzrow T, Hallermann C, Muller S, Schwipper V. Foreign body-induced angiosarcoma 60 years after a shell splinter injury. Mund Kiefer Gesichtschir. 2006; 10:415-8.
El-Bayoumy K, Chung FL, Richie J, et al. Dietary control of cancer. Proc Soc Exp Biol Med. 1997; 216:211-23.
Pinto BM, Trunzo JJ. Health behaviors during and after a cancer diagnosis. Cancer. 2005; 104:2614-23. Errata em: Cancer. 2006; 106:1641.
Hashimoto Y, Skacel M, Adams JC. Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol. 2005; 37:1787-804.
Yoder BJ, Tso E, Skacel M, et al. The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor- negative breast cancer and a more aggressive clinical course. Clin Cancer Res. 2005; 11:186- 92.
Silverman S. Oral cancer: complications of therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 88:122-6.
Martindale. The complete drug reference. 33nded. London: The Pharmaceutical Press; 2002.
Kilickap S, Barista I, Akgul E, Aytemir K, Aksoy A, Tekuzman G. Early and late arrhythmogenic effects of doxorubicin. South Med J. 2007; 100:262-5.
Sonis ST. Oral mucositis in cancer therapy. J Support Oncol. 2004; 2:3-8.
Raut A, Huryn JM, Hwang, FR, Zlotolow, IM. Sequelae and complications related to dental extractions in patients with hematologic malignancies and the impact on medical outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92:49-55.
Coleman S. An overview of oral complications of adult patients with malignant haematological conditions who have undergone radiotherapy or chemotherapy. J Adv Nurs. 1995; 22:1085-91.
Branchi R, Fancelli V, Durval E, De Salvador A. The patient with xerostomia: medical therapy, prosthetic therapy. Minerva Stomatol. 2003; 52:455-63.
Friedlander AH, Friedlande IK, Gallas M, Velasco E. Late-life depression: its oral health significance. Int Dent J. 2003; 53:41-50.
