Saliva, oral implications and biosafety in Dentistry

main aspects in COVID-19

Authors

  • Andrielly Rebeca Fonseca do Nascimento Faculdade Nova Esperança
  • Esllen Carla Ferreira de Araújo Vasconcelos Faculdade Nova Esperança
  • Daniela Figueiredo de Souza Faculdade Nova Esperança
  • Hellen Bandeira de Pontes Santos Faculdade Nova Esperança

DOI:

https://doi.org/10.35699/2178-1990.2021.24587

Keywords:

Coronavirus infections, Saliva, Dentistry, Containment of biohazards

Abstract

Aim: Due to the importance of the salivary fluid in dentistry, this study aimed to carry out a literature review on the relationship between saliva and COVID-19, as well as its main implications in Dentistry.

Methods: An electronic search for publications was performed in the SciELO, PubMed, Scopus, EMBASE, and Cochrane Central Register of Controlled Trials databases using the following descriptors: “Saliva”, “oral cavity”, “oral mucosa”, “oral lesions “, and “Dentistry”, using the Boolean operator “AND” between all keywords cited individually with the term “COVID-19”. The studies were published from December 2019 to September 2020.

Results: The studies have shown that saliva represents an important means of transmission of SARS-CoV-2, which makes it necessary for dentists to comply with biosafety measures in order to reduce the possibility of SARS-CoV-2 infection. Likewise, the high viral load found in saliva allows it to be used as a path to COVID-19 diagnosis. Investigations have shown similar effectiveness in the saliva analysis compared to other conventional techniques. In this regard, more investigations need to be carried out to validate the methodology applied in current studies.

Conclusion: The detection of SARS-CoV-2 through saliva is very promising and has advantages in comparison to other biological fluids, as the collection of this fluid does not involve an invasive intervention, thus facilitating management by professionals and patients.

 

 

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References

in the COVID-19 outbreak. Diagnostics. 2020;10(5):290.

Xu R, Cui B, Duan X, Zhang P, Zhou X, Yuan Q. Saliva: potential diagnostic value and transmission of 2019-nCoV. Int J Oral Sci. 2020;12(1):11.

Ren YF, Rasubala L, Malmstrom H, Eliav E. Dental care and oral health under the clouds of COVID-19. JDR Clin Trans Res. 2020;5(3):202-10.

Khurshid Z, Asiri FYI, Al Wadaani H. Human saliva: non-invasive fluid for detecting novel coronavirus (2019-nCoV). Int J Environ Res Public Health. 2020;17(7):2225.

Fini MB. What dentists need to know about COVID-19. Oral Oncol. 2020;105:104741.

Azzi L, Carcano G, Gianfagna F, Grossi P, Gasperina DD, Genoni A, et al. Saliva is a reliable tool to detect SARS-CoV-2. J Infect. 2020;81(1):e45-e50.

Lo Giudice R. The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) in dentistry. Management of biological risk in dental practice. Int J Environ Res Public Health. 2020;17(9):3067.

Sales PH, Sales PL, Da Hora Sales ML. COVID-2019. How to decrease the risk of infection in dental practice? Minerva Stomatol. 2020.

Fini MB. Oral saliva and COVID-19. Oral Oncol. 2020;108:104821.

To KK, Tsang OT, Yip CC, Chan KH, Wu TC, Chan JM, et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020;71(15):841-43.

Alizargar J, Sh ME, Aghamohammadi M, Hatefi S. Saliva samples as an alternative for novel coronavirus (COVID-19) diagnosis. J Formos Med Assoc. 2020;119(7):1234-5.

Pereira LJ, Pereira CV, Murata RM, Pardi V, Pereira-Dourado SM. Biological and social aspects of Coronavirus Disease 2019 (COVID-19) related to oral health. Braz Oral Res. 2020;34:e041.

Farshidfar N, Hamedani S. Hyposalivation as a potential risk for SARS-CoV-2 infection: Inhibitory role of saliva. Oral Dis. 2020.

Souza WM, Buss LF, Candido DDS, Carrera JP, Li S, Zarebski AE, et al. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. Nat Hum Behav. 2020;4(8):856-65.

Xu J, Li Y, Gan F, Du Y, Yao Y. Salivary glands: potential reservoirs for COVID-19 asymptomatic infection. J Dent Res. 2020;99(8):989.

Sabino-Silva R, Jardim ACG, Siqueira WL. Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clin Oral Investig. 2020;24(4):1619-21.

Wang C, Wu H, Ding X, Ji H, Jiao P, Song H, et al. Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis? Med Hypotheses. 2020;140:109789.

Sri Santosh T, Parmar R, Anand H, Srikanth K, Saritha M. A review of salivary diagnostics and its potential implication in detection of Covid-19. Cureus. 2020;12(4):e7708.

Galhardo LF, Ruivo GF, Oliveira LD, Parize G, Santos SSFD, Pallos D, et al. Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients. Eur J Clin Invest. 2020;50(5):e13219.

Sapkota D, Søland TM, Galtung HK, Sand LP, Giannecchini S, To KKW, et al. COVID-19 salivary signature: diagnostic and research opportunities. J Clin Pathol. 2020.

Williams E, Bond K, Zhang B, Putland M, Williamson DA. Saliva as a noninvasive specimen for detection of SARS-CoV-2. J Clin Microbiol. 2020;58(8):e00776-20.

Nagura-Ikeda M, Imai K, Tabata S, Miyoshi K, Murahara N, Mizuno T, et al. Clinical evaluation of self-collected saliva by quantitative reverse transcription-PCR (RT-qPCR), direct RT-qPCR, reverse transcription-loop-mediated isothermal amplification, and a rapid antigen test to diagnose COVID-19. J Clin Microbiol. 2020;58(9): e01438-20.

Xu R, Cui B, Duan X, Zhang P, Zhou X, Yuan Q. Saliva: potential diagnostic value and transmission of 2019-nCoV. Int J Oral Sci. 2020;12(1):11.

Franco JB, Camargo AR, Peres MPSM. Dental care in the COVID-19 era: recommendations for dental procedures and professionals. Rev Assoc Paul Cir Dent. 2020;74(1):18-21.

25- Bhanushali P, Katge F, Deshpande S, Chimata VK, Shetty S, Pradhan D. COVID-19: Changing trends and its impact on future of dentistry. Int J Dent. 2020;2020:8817424.

Spagnuolo G, De Vito D, Rengo S, Tatullo M. COVID-19 outbreak: an overview on dentistry. Int J Environ Res Public Health. 2020;17(6):2094.

Ge ZY, Yang LM, Xia JJ, Fu XH, Zhang YZ. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020;21(5):361-8.

Muniz IAF, Linden LV, Santos ME, Rodrigues RCS, Souza JR, Oliveira RAS, et al. SARS-CoV-2 and saliva as a diagnostic tool: a real possibility. Pesqui Bras Odontopediatria Clin Integr. 2020;20:e0112.

Published

2022-03-15

How to Cite

Nascimento, A. R. F. do, Vasconcelos, E. C. F. de A. ., Souza, D. F. de, & Santos, H. B. de P. (2022). Saliva, oral implications and biosafety in Dentistry: main aspects in COVID-19. Arquivos Em Odontologia, 57, 114–121. https://doi.org/10.35699/2178-1990.2021.24587

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Artigos