Deriva Imunológica

a história natural dos linfócitos

  • Nelson M. Vaz Universidade Federal de Minas Gerais - UFMG
  • Gustavo C. Ramos Universitätsklinikum Würzburg
  • Kay Saalfeld Universidade Federal de Santa Catarina - UFSC
  • Jorge Mpodozis Universidad de Chile
Palavras-chave: Deriva natural, Imunologia, Exaptação

Resumo

O surgimento do sistema imune na filogênese dos vertebrados mandibulados com sua vasta coleção de receptores linfocitários expressos de forma clonal é usualmente visto como um processo otimizado para a defesa do organismo. Há uma clara associação entre o neodarwinismo, a visão dominante na Biologia atual e a descrição usual da atividade imunológica, conhecida como imunidade adaptativa. Neste texto, sugerimos que toda uma nova abordagem à origem dos sistemas vivos, denominada por Maturana e Mpodozis deriva filogênica natural, aplicada à imunologia, pode substituir a explicação neodarwinista sobre a origem da atividade imunológica. Além disso, pelo emprego dos conceitos de tímpanos (spandrels) e de exaptação, criados por Gould e colaboradores, revemos dados da imunologia comparada e afirmamos que o sistema imune não se formou como um sistema otimizado para a defesa do organismo, mas pode ser visto como um tímpano (spandrel), uma consequência de processos que originalmente não estavam relacionados a interações do organismo com materiais estranhos. Afirmamos também que a inserção de linfócitos na dinâmica do organismo era necessária para contornar o potencial imunopatogênico de expansões clonais.

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Biografia do Autor

Nelson M. Vaz, Universidade Federal de Minas Gerais - UFMG

Professor do Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG)

Gustavo C. Ramos, Universitätsklinikum Würzburg

Bolsista PDE/CNPq, Deutsches Zentrum für Herzinsuffizienz, Universitätsklinikum Würzburg

Kay Saalfeld, Universidade Federal de Santa Catarina - UFSC

Professor do Departamento de Ecologia, Universidade Federal de Santa Catarina (UFSC)

Jorge Mpodozis, Universidad de Chile

Professor Facultad de Ciencias, Departamento de Biologia, Universidad de Chile

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Publicado
2016-04-07
Como Citar
VAZ, N. M.; RAMOS, G. C.; SAALFELD, K.; MPODOZIS, J. Deriva Imunológica. Revista da Universidade Federal de Minas Gerais, v. 21, n. 1 e 2, p. 60-87, 7 abr. 2016.
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