Stomatologic lesions in HIV infected children and their clinical implications
Keywords:
HIV, Oral manifestations, Pediatric DentistryAbstract
Oral lesions are common in HIV infected children. These illnesses are related to the patients’ general state of health and their prognosis when undergoing Highly Active Antiretroviral Therapy (HAART). The aim of this article is to describe, according to reports in scientific literature, the main stomatologic lesions associated with HIV in children, detailing their clinical features, diagnosis, and possible treatments, and with this, attempt to aid in intraoral exams and patient follow-ups.
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Louis D. Human Immunodeficiency virus disease: natural history and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:266-70.
Schmidt-Westhausen AM, Priepke F, Bergman FJ, Reichart PA. Decline in the rate of oral opportunistic infections following introduction of highly active antiretroviral therapy. J Oral Pathol Med. 2000;29:336-41.
Tappuni AR, Fleming GJP. The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:623-8.
Spire B, Duran S, Souville M, Leport C, Raffi F, Moatti JP. Adherence of highly active antiretroviral therapies (HAART) in HIVinfected patients: from a predictive to a dynamic approach. Soc Sci & Med. 2002;54:1481-96.
Lopes SMP, Gonzaga HFS, Lopes MA, Vargas PA. Manifestações bucais associadas à Síndrome da Imunodeficiência Adquirida. J Bras Med. 2004;96:11-5.
Leggott PJ. Oral Manifestations of HIV infection in children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1992;73:187-92.
AIDS Institute. Criteria for the medical care of children and adolescents with HIV infection. New York: Department of Health; 1998.
Guidelines for the use antiretroviral agents in pediatric HIV infection. New York: Working Group on Antiretroviral Therapy and Medical Management of HIV-infected Children; 2000.
Oxtoby MJ. Perinatally acquired human immunodeficiency virus infection. Pediatr Infect Dis J. 1996;9:609-19.
Centers for disease control. HIV/AIDS Surveillance. Atlanta: Department of Health and Human Services; 1994.
Magalhães MG, Bueno DF, Serra E, Gonçalves R. Oral manifestations of HIV positive children. J Clin Pediatr Dent. 2001;25:103-6.
Mofenson LM. Current insights regarding vertical transmission. In: Pizzo AP, Wilferts CM. Pediatric AIDS: the challenge of HIV infection in infants, children and adolescents. 2ªed. Williams and Wilkins; 1994. p.190-1.
Sonis ST, Fazio RC, Fang L. Princípios e prática de medicina oral. 2ªed. Rio de Janeiro: Guanabara-Koogan; 1996.
Tunkel DE, Loury MC, Fox, CH, Goins MA, Johns EE. Bilateral parotid enlargement in HIVseropositive patients. Laryngoscope. 1989;99:590-5.
Ramos-Gomez FJ, Flaitz C, Catapano P, Murray P, Milnes AR, Dorenbaum A. Classification, diagnostic criteria and treatment recommendations for orofacial manifestations in HIV-infected pediatric patients. J Clin Pediatric Dent. 1999;23:85-96.
Santos LC, Castro GF, Souza IPR, Oliveira RHS. Oral manifestations related to immunosuppression degree in HIV-positive children. Braz Dent J. 2001;12:135-8.
Katz MH, Mastrucci MT, Leggott PJ, Westenhouse J, Greenspan JP, Scott GB. Prognostic significance of oral lesions in children with perinatally acquired human immunodeficiency virus infection. Am J Dis Child. 1993;147:45-8.
Howell RB, Jandinski JJ, Palumbo P, Shey Z, Houpt MI. Oral soft tissue manifestations and CD4 lymphocyte counts in HIV-infected children. Pediatr Dent. 1996;18:117-20.
Grando LJ, Yurgel LS, Machado DC, et al. Manifestações estomatológicas, contagem de linfócitos TCD4+ e carga viral de crianças brasileiras e norte-americanas infectadas pelo HIV. Pesqui Odontol Bras. 2002;16:18-25.
Samaranayake LP. Oral mycoses in HIV infection. Oral Surg Oral Med Oral Pathol. 1993;73:171-80.
Chigurupati R, Raghavan SS, Studen-Pavlovich DA. Pediatric HIV infection and its oral manifestations: a review. Pediatr Dent. 1996;18:106-12.
Lasskaris G. Infecção pelo HIV e AIDS In:Atlas Colorido de Doenças Bucais da Infância e da Adolescência. Artes médicas Sul; 2000. p.250-9.
Castro GF. Infecção pelo HIV em crianças e suas manifestações bucais: revisão de literatura. JBP J Bras Odontopediatr Odontol Bebê. 1999;2:223-30.
Prose N. Guidelines for treatment of skin disease for children with HIV infection. J Pediatr. 1991;119:57-8.
Viscoli C, Castagnola E, Fioredda F, Ciravegna B, Barigione G, Terragna A. Fluconazole in the treatment of candidiasis in immunocompromissed children. Antimicrob Agents Chemother.1991;35:365-7.
Hernandez-Sampelayo T. Fluconazole versus ketoconazole in the treatment of oropharyngeal candidiasis in HIV-infected children: multicentre study group. Eur J Clin Microbiol Infect Dis. 1994;13:340-4.
Martin MV. The use of fluconazole in the treatment of candida albicans infection: a review. J Antimicrob Chemother. 1999;44:429-37.
Studen-Pavlovich D, Chigurupati R. Oral manifestations in HIV infected children. Penn Dent J. 1997;64:17-23.
Costa LRRS, Villena RS, Birman EG. Oral findings in pediatric Aids: a case control study in Brazilian children. ASDC J Dent Child. 1998;65:186-90.
Chan A, Milnes A, King SM, Read S. The relationship of oral manifestations to parameters of immune function and CDC stage in children born to HIV: positive women. Pediatr AIDS HIV Infect. 1994;5:101-7.
Rubinstein A. Pediatric AIDS. Curr Probl Pediatr. 1986;16:361-409.
De Martino M. Features of children perinatally infected with HIV-1 surviving longer than five years: italian register of HIV infection in children. Lancet. 1994;343:1191-5.
Schiodt M. HIV: associated salivary gland disease: a review. Oral Surg Oral Med Oral Pathol. 1992;73:164-7.
Mitsuya H, Weinhold KJ, Furman PA, Clair HS, Lehrman SN, Gallo RC, et al. 3´-Azido-3´ deoxythymidine (BWA509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/ lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci USA. 1985;82:7096-100.
Fischl MA, Parker CB, Pettinelli C, Wulfsohn M, Hirsch MS, Collier AC, et al. A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1990; 323:1009-14.
Mckinney RE, Maha MA, Connor EM, Feinberg J, Scott GB, Wufsohn M, et al. A multicenter trial of oral zidovudine in children with advanced human immunodeficiency virus disease. N Engl J Med. 1991;324:1018-25.
Tommasi AF. Diagnóstico em patologia bucal. 2ªed. São Paulo: Pancast. 1989. 38. Del Toro A, Berkowitz R, Meyerowitz C, Frenkel
M. Oral findings in asymptomatic (P-1) and symptomatic (P-2) HIV infected children. Pediatr Dent. 1996;18:114-6.
Jotornirski F. AIDS & Odontologia. Secretaria de Estado da Saúde do Paraná/Coordenação Estadual de D.S.T e AIDS, 1998. [acesso em 2007 ago 08]. Disponível em: http://www.cror j . o r g . b r / b i o s s e g u r a n ç a / AIDS&Odontologia.doc.
Gilman, AG. As Bases Farmacológicas da Terapêutica. 9ªed. Rio de Janeiro: McGraw-Hill Interamericana; 1996.
Moniaci D, Cavallari M, Greco D, Bruatto M, Raiteri R, Paloma E, et al. Oral lesions in children born to HIV-1 positive women. J Oral Pathol Med. 1993; 22:8-11.
Nicolatou O, Theodoridou M, Mostrou G, Velegraki A, Legakis NJ. Oral lesions in children with perinatally acquired human immunodeficiency virus infection. J Oral Pathol Med 1999;28:49-53.
