Drug interactions prevalence involving high-surveillance drugs:
a crosssectional study
DOI:
https://doi.org/10.5935/1415-2762.20190074Keywords:
Patient Safety, Safety Management, Drug InteractionsAbstract
Objective: to estimate the prevalence of potential drug interactions (PDIs) related to the high-surveillance drugs (HSD) used by a sample of patients admitted to an
intensive care unit (ICU). Methods: a cross-sectional, retrospective study with a quantitative approach. Research was based on the analysis of patients prescriptions admitted to the ICU over a one-year period (2014-2015) to identify potential drug interactions related to recurrent HSDs. For each medical record, they were analyzed from the first three to five prescriptions, depending on their availability and the period of individual hospitalization. PDIs identification was made by consulting the Trissels device from the Micromedex 2.0 database. Results: in the 244 drug prescriptions, 846 HSD-related PDIs and 112 different pairs of PDI involving the HSDs were identified. The main HSDs in PDI were: regular insulin, midazolam, fentanyl and tramadol. Of the 112 types of identified PDI, some were recurrent; namely: tramadol and ondansetron, fentanyl and midazolam, midazolam and omeprazole, regular insulin and hydrocortisone, as well as regular insulin and norepinephrine. HSD with PDIs prevalence in this sample was 0.96 (96%). Conclusion: most patients were exposed to PDI involving midazolam, fentanyl or regular insulin. Some vigilance should be established to avoid unnecessary interactions. Alternatively, when the joint administration of certain interactants is indispensable skills should be in place to manage this administration more appropriately and with the lowest possible risk to the patient.
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