Day zero of hematopoietic stem cell transplantation

nurse's care

Authors

  • Talita Wérica Borges Figueiredo Universidade Federal do Paraná, Departamento de Enfermagem, Curitiba PR , Brazil, Enfermeira. Mestranda. Universidade Federal do Paraná - UFPR, Departamento de Enfermagem. Curitiba, PR - Brasil, Universidade Federal do Paraná
  • Nen Nalú Alves das Mercês UFPR, Departamento de Enfermagem, Curitiba PR , Brazil, Enfermeira. Doutora em Enfermagem. Professora Adjunta. UFPR, Departamento de Enfermagem. Curitiba, PR - Brasil, Universidade Federal do Paraná

DOI:

https://doi.org/10.5935/1415-2762.20170059

Keywords:

Nursing, Nursing Care, Hematopoietic Stem Cell Transplantation

Abstract

The aim of the study was to identify the care provided by nurses on the Day Zero of Transplantation of hematopoietic stem cells and identify the adverse reactions presented by patients on this day. A descriptive study of qualitative approach was conducted at the inpatient unit of a bone marrow transplant service of a university hospital in the southern region of Brazil. Eleven nurses participated in the study. The data collection period was between July and September of 2016 during a total of ten days of transplantations and 72 hours of passive observation. Data were recorded in a previously prepared instrument and analyzed in pre-established categories. Related and unrelated allogeneic transplantations were observed, in which the hematopoietic stem cells used were bone marrow, peripheral blood, and umbilical and placental cord blood. The infusion modalities observed were cryopreserved and fresh. ABO compatibility in the fresh modality consisted in the categories ABO-compatible, major ABO-incompatible and minor ABO-incompatible. Adverse reactions were observed in eight out of the ten transplantations, and the most prevalent was systemic arterial hypertension. Nursing care consisted in actions implemented before, during and after the infusion of hematopoietic stem cells, among them: administration of medications prescribed by the physician previously to infusion of hematopoietic stem cells (before); monitoring of vital signs (during), monitoring of appearance and volume of diuresis and water balance (after). The conclusion was that care provided to patients by nurses on Day Zero of Hematopoietic Stem Cell Transplantation aims at early prevention, detection and intervention in adverse reactions related to the hematopoietic stem cell infusion procedure.

Downloads

Download data is not yet available.

References

Timuragaoglu A. The role of the nurses and technicians for stem cell mobilization and collection.Transfus Apheresis Sci. 2015[citado em 2017 mar. 17];53(1):30-3. Disponível em: http://www.sciencedirect.com/science/article/pii/S1473050215001056

Tormey CA, Snyder EL. Hematopoietic progenitor cell administration. In: Wingard JR, Gastineau DA, Leather HL, Snyder EL, Szczepiokowski ZM, editors. Hematopoietic stem cell transplantation: a handbook for clinicians. 2nd ed. Bethesda: American Association of Blood Banks; 2015. p. 239-53.

Lima K, Bernardino E. Nursing care in a Hematopoietic stem cell transplantation unit. Texto Contexto Enferm. 2014[citado em 2017 abr. 15];23(4):845-53. Disponível em: http://www.scielo.br/pdf/tce/v23n4/0104-0707-tce-23-04-00845.pdf

Conselho Federal de Enfermagem (COFEN). Resolução nº 200, de 15 de abril de 1997. Dispõe sobre a atuação dos profissionais de enfermagem em hemoterapia e transplante de medula óssea. Brasília: COFEN; 1997. [citado em 2017 abr. 01]. Disponível em: http://www.cofen.gov.br/resoluo-cofen-2001997-revogada-pela-resoluo-3062006_4254.html

Curcioli ACJV, Carvalho EC. Infusion of hematopoietic stem cells: types, characteristics, adverse and transfusion reactions and the implications for nursing. Rev Latino-Am Enferm. 2010[citado em 2017 maio 02];18(4):716-24. Disponível em: http://www.scielo.br/pdf/rlae/v18n4/09.pdf

American Association of Blood Banks (AABB). Circular of information for the use of cellular therapy products. Bethesda: AABB, 2016. [citado em 2017 mar. 23]. Disponível em: https://www.aabb.org/tm/coi/Documents/coi1113.pdf

Shu Z, Heimfeld S, Gao D. Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion. Bone Marrow Transplant. 2014[citado em 2017 mar. 15];49(4):469-76. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420483/

Freire NCB, Rodrigues AB, Almeida PC, Costa LS, Duarte FB. Adverse reactions related to hematopoietic stem cell infusion. Rev Enferm UFPE on line. 2015[citado em 2017 abr. 22];9(1):391-8. Disponível em: http://www.revista.ufpe.br/revistaenfermagem/index.php/revista/article/view/5537/pdf_7037

Vidula N, Villa M, Helenowski IB, Merchant M, Jovanovic BD, Meagher R, et al. Adverse events during hematopoietic stem cell infusion: analysis of the infusion product. Clin Lymphoma Myeloma Leuk. 2015[citado em 2017 maio 22];15(11):157-62. Disponível em: http://www.sciencedirect.com/science/article/pii/S2152265015012434

Patrick K, Lau W, Gassas A, McDougall E, Dolye J, Ali M, et al. Major ABO incompatible BMT in children: determining what residual volume of donor red cells can safely be infused following red cell depletion. Bone Marrow Transplant. 2015[citado em 2017 maio 12];50(4):536-9. Disponível em: http://www.nature.com/bmt/journal/v50/n4/pdf/bmt2014309a.pdf

Eisenberg S, Wickline M, Linenberger M, Gooley T, Holmberg L. Prevention of Dimethylsulfoxide-related nausea and vomiting by prophylatic administration of ondansetron for patients receiving autologous cryopreserved peripheral blood stem cells. Oncol Nurs Forum. 2013[citado em 2017 abr. 23];40(3):285-92. Disponível em: https://onf.ons.org/onf/40/3/preventiondimethylsulfoxide-related-nausea-and-vomiting-prophylactic-administration

Conselho Nacional de Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Aprova as diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Brasília: CNS; 2012. [citado em 2017 maio 25]. Disponível em: http://conselho.saude.gov.br/resolucoes/2012/Reso466.pdf

Holtick U, Albrecht M, Chemnitz JM, Theurich S, Shimabukuro-Vornhagen A, Skoetz N, et al. Comparison of bone marrow versus peripheral blood allogeneic hematopoietic stem cell transplantation for hematological malignancies in adults - a systematic review and meta-analysis. Crit Rev Oncol Hematol. 2014[citado em 2017 mar. 25];94(2):179-88. Disponível em: http://www.croh-online.com/article/S1040-8428(14)00215-7/pdf

Ministério da Saúde (BR). Resolução RDC n. 56, de 16 de dezembro de 2010. Dispõe sobre o regulamento técnico para o funcionamento dos laboratórios de processamento de células progenitoras hematopoéticas (CPH) provenientes de medula óssea e sangue periférico e bancos de sangue de cordão umbilical e placentário, para finalidade de transplante convencional e dá outras providências. Brasília: MS; 2010. [citado em 2017 mar. 23]. Disponível em: http://www.hemoce.ce.gov.br/images/Artigos/rdc_56_2010_hemoterapia.pdf

Kopko PM. Transfusion support for ABO-Incompatible progenitor cell transplantation. Transfus Med Hemother. 2016[citado em 2017 abr. 02];43(1):13-8. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797464/pdf/tmh-0043-0013.pdf

Staley EM, Schwartz J, Pham HP. An update on ABO incompatible hematopoietic progenitor cell transplantation. Transfus Apheresis Sci. 2016[citado em 2017 maio 01];54(3):337-44. Disponível em: http://www.trasci.com/article/S1473-0502(16)30029-5/pdf

Curley C, Pillai E, Mudie K, Western R, Hutchins C, Durrant S, et al. Outcomes after major or bidirectional ABO-mismatched allogeneic hematopoietic progenitor cell transplantation after pretransplant isoagglutinin reduction with donor-type secretor plasma with or without plasma exchange. Transfusion. 2012[citado em 2017 maio 02];52(2):291-7. Disponível em: http://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2011.03295.x/epdf

Regan DM, Wofford JD, Wall DA. Comparison of cord blood thawing methods on cell recovery, potency, and infusion. Transfusion. 2010[citado em 2017 mar. 30];50(12):2670-5. Disponível em: http://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2010.02803.x/epdf

Mulay SB, Greiner CW, Mohr A, Bryant SC, Lingineni RK, Padley D, et al. Infusion technique of hematopoietic progenitor cells and related adverse events. Transfusion. 2014[citado em 2017 abr. 05];54(8):1997-2003. Disponível em: http://onlinelibrary.wiley.com/doi/10.1111/trf.12572/epdf

Ikeda ALC, Cruz FBJ, Rosa LM. Collection and infusion stem cells hematopoietic: nursing, technology and teaching-learning. Rev Enferm UFPE on line. 2015[citado em 2017 mar. 28];9(2):896-901. Disponível em: http://www.revista.ufpe.br/revistaenfermagem/index.php/revista/article/view/5947/pdf_7291

Potter P, Eisenberg S, Cain KC, Berry Dl. Orange interventions for symptoms associated with dimethyl sulfoxide during stem cell reinfusions: a feasibility study. Cancer Nurs. 2011[citado em 2017 abr. 23];34(5):361-8. Disponível em: http://www.ncbi.nlm.nih.gov/pubmed/21372706

Fry LJ, Querol S, Gomez SG, McArdle S, Rees R, Madrigal JA. Assessing the toxic effects of DMSO on cord blood to determine exposure time limits and the optimum concentration for cryopreservation. Vox Sang. 2015[citado em 2017 maio 01];109(2):181-90. Disponível em: http://onlinelibrary.wiley.com/doi/10.1111/vox.12267/epdf

Harden KL, Lorenz A, Conn S. Happy birthday…again: educating BMT nurses and patients about infusion of stem cells. In: BMT Tandem Meetings. Poster Abstracts. 2015[citado em 2017 abr. 22];21:S374-S390. Disponível em: https://bmt.confex.com/tandem/2015/webprogram/Paper5067.html

Published

2018-03-05

Issue

Section

Research

How to Cite

1.
Day zero of hematopoietic stem cell transplantation: nurse’s care. REME Rev Min Enferm. [Internet]. 2018 Mar. 5 [cited 2025 Dec. 8];21. Available from: https://periodicos.ufmg.br/index.php/reme/article/view/49847

Most read articles by the same author(s)