Brazil and the crossbreed idiosyncrasy
DOI:
https://doi.org/10.35699/2316-770X.2015.2748Keywords:
Human population genetics, Brazilian history, Biological anthropologyAbstract
The EPIGEN-Brazil initiative is a strategic project of the Brazilian Ministry of Health, and is the largest LatinAmerican initiative for the study of human genetic diversity. It integrates two important Brazilian scientific traditions: Public Health and Human Population Genetics. In the context of the results of the EPIGEN-Brazil Project, we discuss how population genetics studies contribute to understand the process of crossbreed in Brazil, and its implications in Public Health. We show how the high genomic resolution of the EPIGEN-Brazil Project and the state-of-the-art computational methodologies allowed new inferences on the origin and dynamics of crossbreed, as well as to understand how the Brazilian social history influenced the genetic structure of this population.
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ALVES-Silva, J.; DA SILVA SANTOS, M.; GUIMARÃES, P.E.; FERREIRA, A.C.; BANDELT, H.J.; PENA,S.D.; Prado, V.F.The ancestry of Brazilian mtDNA lineages. Am J Hum Genet. 67(3):775. Sep 2001.
BARRETO, M.L.; Cunha, S.S.; ALCÂNTARA-NEVES, N.; CARVALHO, L.P.; CRUZ, A.A.; STEIN, R.T.; GENSER, B.; COOPER, P.J.; RODRIGUES, L.C. Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study). BMC Pulm Med. 6:15. Jun 2006.
CARVALHO-SILVA, D.R.; SANTOS, F.R.; ROCHA, J.; PENA, S.D. The phylogeography of Brazilian Y-chromosome lineages. Am J Hum Genet. 68(1):281-6. Jan 2000.
CASTILLA, E.E.; SCHULER-FACCINI, L. From rumors to genetic isolates. Genet Mol Biol. 2014 Mar; 37 (1 Suppl):186-93.
FREIRE-MAIA, N. Genetic effects in Brazilian populations due to consanguineous marriages. Am J Med Genet. 35(1):115-7. Jan 1990.
GIOLO, S.R.; Soler, J.M.; GREENWAY, S.C.; ALMEIDA, M.A.; de ANDRADE, M.; SEIDMAN, J.G.; SEIDMAN, C.E.; KRIEGER, J.E.; PEREIRA, A.C. Brazilian urban population genetic structure reveals a high degree of admixture. Eur J Hum Genet. 20(1):111-6. Jan 2012.
KEHDY, F.S.; GOUVEIA, M.H.; MACHADO, M.; MAGALHÃES, W.C.; HORIMOTO, A.R.; HORTA, B.L.; MOREIRA, R.G.; LEAL, T.P.; SCLIAR, M.O.; SOARES-SOUZA, G.B.; RODRIGUES-SOARES, F.; ARAÚJO, G.S.; ZAMUDIO, R.; SANT ANNA, H.P.; SANTOS, H.C.; DUARTE, N.E.; FIACCONE, R.L.; FIGUEIREDO, C.A.; SILVA, T.M.; COSTA, G.N.; BELEZA, S.; BERG, D.E.; CABRERA, L.; DEBORTOLI, G.; DUARTE, D.; GHIROTTO, S.; GILMAN, R.H.; GONÇALVES, V.F.; MARRERO, A.R.; MUNIZ, Y.C.; WEISSENSTEINER, H.; YEAGER, M.; RODRIGUES, L.C.; BARRETO, M.L.; Lima-Costa, M.F.; PEREIRA, A.C.; RODRIGUES, M.R.; TARAZONA-SANTOS, E.; Brazilian EPIGEN Project Consortium. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc Natl Acad Sci U S A. 14; 112 (28):8696-701. Jul 2015.
KOHLRAUSCH, F.; MAGNO, L.A.; MONTENEGRO, R.C.; MORAES, M.O.; de MORAES, M.E.; DE MORAES, M.R.; OJOPI, E.B.; PERINI, J.A.; RACCIOPI, C.; RIBEIRO-DOS-SANTOS, A.K.; RIOS-SANTOS, F.; ROMANO-SILVA, M.A.; SORTICA, V.A.; SUAREZ-KURTZ, G. The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. PLoS One. 16;6 (2):e17063. Feb 2011.
KRIEGER, H.; MORTON, N.E.; MI, M.P.; AZEVÊDO, E.; FREIRE-MAIA, A.; YASUDA, N. Racial admixture in north-eastern Brazil. Ann Hum Genet. 29(2):113-25. Nov 1965.
KUHN, P.C.; HORIMOTO, A.R.; SANCHES, J.M.; VIEIRA FILHO, J.P.; FRANCO, L.; FABBRO, A.D.; FRANCO, L.J.; PEREIRA, A.C.; MOISES, R.S. Genome-wide analysis in Brazilian Xavante Indians reveals low degree of admixture. PLoS One.7(8):e42702. 2012.
LACOMBE; A.J.; SILVA, E.; Barbosa, F.A. Rui Barbosa e a Queima dos Arquivos. Rio de Janeiro: Fundação Casa de Rui Barbosa, 1988.
LIMA-COSTA, M.F.; FIRMO, J.O.; Uchoa, E. Cohort profile: the Bambui (Brazil) Cohort Study of Ageing. Int J Epidemiol. 40(4):862-7. Aug 2011.
LIMA-COSTA, M.F.; RODRIGUES, L.C.; BARRETO, M.L.; GOUVEIA. M.; HORTA, B.L.; MAMBRINI, J.; KEHDY, F.S.; PEREIRA, A.; RODRIGUES-SOARES, F.; VICTORA, C.G.; TARAZONA-SANTOS, E.; Epigen-Brazil group. Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative). Sci Rep27;5:9812. Apr 2015.
MOURA, R.R.; COELHO, A.V.; BALBINO, V.de Q.; CROVELLA, S.; BRANDÃO, L.A. Meta-analysis of Brazilian genetic admixture and comparison with other Latin America countries. Am J Hum Biol. 27(5):674-80. Sep-Oct 2015.
PARRA, F.C.; AMADO, R.C.; LAMBERTUCCI, J.R.; ROCHA, J.; ANTUNES, C.M., PENA, S.D. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci U S A. 7;100(1):177-82. 30 Dec 2003.
PENA S.D; Carvalho-Silva, D.R.; Alves-Silva, J.; Prado, V.F. Retrato Molecular do Brasil. Ciência Hoje. São Paulo, v. 159, n. 27, Abril, 2000.
PENA, S.D.; Di PIETRO, G.; FUCHSHUBER-MORAES, M.; GENRO, J.P.; HUTZ, M.H.; KEHDY, F.; RUIZ-LINARES, A.; ADHIKARI, K.; ACUÑA-ALONZO, V.; QUINTO-SANCHEZ, M.; JARAMILLO, C.; ARIAS, W.; FUENTES, M.; PIZARRO, M.; EVERARDO, P.; DE AVILA, F.; GÓMEZ-VALDÉS, J.; LEÓN-MIMILA, P.; HUNEMEIER, T.; RAMALLO, V.; SILVA DE CERQUEIRA, C.C.; BURLEY, M.W.; KONCA, E.; DE OLIVEIRA, M.Z.; VERONEZ, M.R.; RUBIO-CODINA, M.; ATTANASIO, O.; GIBBON, S.; RAY, N.; GALLO, C.; POLETTI, G.; ROSIQUE, J.; SCHULER-FACCINI, L.; SALZANO, F.M.; BORTOLINI, M.C.; CANIZALES-QUINTEROS, S.; ROTHHAMMER, F.; BEDOYA, G.; BALDING, D.; GONZALEZ-JOSÉ, R. Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals. PLoS Genet. 5;10(9):e1004572. Sep 2014.
SALZANO F.M.; FREIRE-MAIA, N. Populações Brasileiras, aspectos demográficos, genéticos e antropológicos. São Paulo : Cia. Ed. Nacional, Ed. da Universidade 1967.
SALZANO F.M.; BORTOLINI, M.C. The Evolution and Genetics of Latin American Populations. Cambridge. Cambridge University Press. 2005.
SCLIAR, M.O.; VAINTRAUB, M.T.; VAINTRAUB, P.M.; FONSECA, C.G. Brief communication: Admixture analysis with forensic microsatellites in Minas Gerais, Brazil: the ongoing evolution of the capital and of an African-derived community. Am J Phys Anthropol.139(4):591-5. Aug 2009.
SOUZA, V.S.; SANTOS, R.V. The emergence of human population genetics and narratives about the formation of the Brazilian nation (1950-1960). Stud Hist Philos Biol Biomed Sci. 47:97-107. September 2014.
SUAREZ-KURTZ, G.; PENA, S.D.; STRUCHINER, C.J.; HUTZ, M.H. Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin. Front Pharmacol. 6; 3:191. Nov 2012.
TELLES, E.E. Race in Another America: The Significance of Skin Color in Brazil. New Jersey: Princeton University Press, 2004.
VICTORA, C.G.; BARROS, F.C. Cohort profile: the 1982 Pelotas (Brazil) birth cohort study. Int J Epidemiol. 35(2):237-42. Apr 2006. Epub. Review. Dec 2005.