Diversity in immunology
DOI:
https://doi.org/10.35699/2316-770X.2015.2749Keywords:
Immunology, Specificity, DegenerationAbstract
In the generation of immunological diversity, millions of different cells (such as lymphocytes), and molecules
(antibodies) are assembled by somatic processes, de novo in each vertebrate organism. The genes involved in the lymphocyte activation and antibody production are not inherited as whole genes. Lymphocytes and antibodies, different from one another, react with each other and form a complex multiconnected network – the immune system – in which complexity is essential. Reductions in (lymphocyte clonal) diversity (oligoclonal expansions) are associated with severe forms of infectious, allergic and autoimmune diseases. Current immunology is learning to deal with systemic approaches in which clonal diversity is important in the associations with the native microbiome and dietary proteins.
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