The top 100 most-cited clinical trials and systematic reviews related to children and adolescents’ oral health

A bibliometric analysis


  • Karina Maria Pires Federal University of Santa Catarina
  • Filipe Colombo Vitali Federal University of Santa Catarina
  • Pablo Silveira Santos Federal University of Santa Catarina
  • Michele Bolan Federal University of Santa Catarina
  • Paulo Antônio Martins-Júnior Federal University of Minas Gerais
  • Mariane Cardoso Federal University of Santa Catarina
  • Carla Miranda Santana Federal University of Santa Catarina



Bibliometrics, Clinical Trial, Pediatric Dentistry, Systematic Review


Aim: To identify and analyze the 100 most-cited clinical trials (CTs) and systematic reviews (SRs) related to children and adolescents’ oral health.

Methods: A search was conducted in the Web of Science Core Collection (WoS-CC), using a specific search strategy. Papers were ranked in descending order, considering number of citations. Only CTs and SRs were considered. Two reviewers selected the papers and collected the bibliometric data: year of publication; number and density of citations; study designs; journals; authors; countries and institutions; topics of study; and keywords. Poisson regression was performed to verify associations between the number of citations and bibliometric parameters.

Results: The 100 most-cited papers were published between 1982 and 2018 and received a total of 8,702 citations in the WoS-CC (ranging from 52 to 177). Fifty-three papers were CTs and 47 SRs. The American Journal of Orthodontics and Dentofacial Orthopedics published the most papers (n=20). Twetman S contributed the highest number of papers (n=7). The United States of America was the most prolific country (n = 17), followed by the Netherlands (n=11). The University of Nijmegen (Netherlands) presented 8 papers among the most-cited. The main topic of interest was Cariology (n = 40). “Dental Caries” was the most frequent keyword (n = 20). The citations’ number from WoS-CC decreased by 1.3% each year (RP: 0.987, 95%CI: 0.975–1.000, p = 0.048).

Conclusion: This bibliometric study allowed an analysis of the most-cited CTs and SRs related to children and adolescents’ oral health, highlighting the most prolific authors, institutions and countries based on the number of citations.


Download data is not yet available.


Chiappelli F. Evidence-Based Dentistry: Two decades and beyond. J Evid Based Dent Pract. 2019;19:7-16.

Sellars S. How evidence-based is dentistry anyway? From evidence-based dentistry to evidence-based practice. Br Dent J. 2020;229:12-14.

Kupietzky A, Fuks A. The keeper of the meaning and the Era of Evidence Based Dentistry. Pediatr Dent. 2018;40:250-252.

Jayaratne YS, Zwahlen RA. The evolution of dental journals from 2003 to 2012: a bibliometric analysis. PloS 2015;10:e0119503.

Hirsch JE. An index to quantify an individual's scientific research output. Proc Natl Acad Sci U S A. 2005;102:16569-16572.

Roldan-Valadez E, Salazar-Ruiz SY, Ibarra-Contreras R, Rios C. Current concepts on bibliometrics: a brief review about impact factor, Eigenfactor score, CiteScore, SCImago Journal Rank, Source-Normalised Impact per Paper, H-index, and alternative metrics. Ir J Med Sci. 2019;188:939-951.

Perazzo MF, Otoni ALC, Costa MS, Granville-Granville AF, Paiva SM, Martins-Júnior PA. The top 100 most-cited papers in Paediatric Dentistry journals: A bibliometric analysis. Int J Paediatr Dent. 2019;29:692-711.

Vitali FC, Pires KM, Cardoso IV, et al. Endodontic therapy in primary teeth: a bibliometric analysis of the 100 most-cited papers. Braz Oral Res. 2022;36:e049.

Gogos C, Kodonas K, Fardi A, Economides N. Top 100 cited systematic reviews and meta-analyses in dentistry. Acta odontol Scand. 2020;78:87-97.

Fardi A, Kodonas K, Gogos C, Economides N. Top-cited articles in endodontic journals. J Endod. 2011;37:1183-1190.

Ohta L, O'Brien B, Knight H, Patel J, Anthonappa RP. Publication trends in Pediatric Dentistry Journal: A 20-year bibliometric analysis (1999-2018). Pediatr Dent. 2020;42:354-358.

Dos Santos APP, Raggio DP, Nadanovsky P. Reference is not evidence. Int J Paediatr Dent. 2020;30:661-663.

Chu CH, Lo EC, Lin HC. Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. J Dent Res. 2002;81:767-770.

Soncini JA, Maserejian NN, Trachtenberg F, Tavares M, Hayes C. The longevity of amalgam versus compomer/composite restorations in posterior primary and permanent teeth: findings from the New England Children's Amalgam Trial. J Am Dent Assoc. 2007;138:763-772.

Twetman S, Axelsson S, Dahlgren H, et al. Caries-preventive effect of fluoride toothpaste: a systematic review. Acta Odontol Scand. 2003;61:347-355.

Schwendicke F, Elhennawy K, Reda S, Bekes K, Manton DJ, Krois J. Global burden of molar incisor hypomineralization. J Dent. 2018;68:10-18.

Lang NP, Hotz P, Graf H, et al. Effects of supervised chlorhexidine mouthrinses in children. A longitudinal clinical trial. J Period Res. 982;17:101-111.

Andersen J, Belmont J, Cho CT. Journal impact factor in the era of expanding literature. J Microbiol Immunol Infect. 2006;39:436-443.

Feijoo JF, Limeres J, Fernández-Varela M, Ramos I, Diz P. The 100 most cited articles in dentistry. Clin Oral Investig. 2014;18:699-706.

da Costa Rosa T, Pintor AVB, Magno MB, Marañón-Vásquez GA, Maia LC, Neves AA. Worldwide trends on molar incisor and deciduous molar hypomineralisation research: a bibliometric analysis over a 19-year period. Eur Arch Paediat Dent. 2022;23:133-146.

Jiang CM, Lee GHM, Lo ECM, Chu CH, Wong MCM. Randomized controlled trials in dental journals on children and adolescents: a bibliometric analysis. J Evid Based Dent Pract. 2021;21:101621.

Hopper L, Morris L, Tickle M. How primary care dentists perceive and are influenced by research. Community Dent Oral Epidemiol. 2011;39:97-104.

Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of untreated caries: a systematic review and metaregression. J Dent Res. 2015;94:650-658.

Shadgan B, Roig M, Hajghanbari B, Reid WD. Top-cited articles in rehabilitation. Arch Phys Med Rehabil. 2010;91:806-815.

Ahmad P, Dummer PMH, Chaudhry A, Rashid U, Saif S, Asif JA. A bibliometric study of the top 100 most-cited randomized controlled trials, systematic reviews and meta-analyses published in endodontic journals. Int Endod J. 2019;52:1297-1316.

Bakkalbasi N, Bauer K, Glover J, Wang L. Three options for citation tracking: Google Scholar, Scopus and Web of Science. Biomed Digit Libr. 2006;3:7.

Kulkarni AV, Aziz B, Shams I, Busse JW. Comparisons of citations in Web of Science, Scopus, and Google Scholar for articles published in general medical journals. Jama. 2009;302:1092-1096.

Livas C, Delli K. Journal Self-Citation Rates and Impact Factors in Dentistry, Oral Surgery, and Medicine: A 3-year Bibliometric Analysis. J Evid Based Dent Pract. 2018;18:269-274.




How to Cite

Pires, K. M., Vitali, F. C., Santos, P. S., Bolan, M., Martins-Júnior, P. A., Cardoso, M., & Santana, C. M. (2024). The top 100 most-cited clinical trials and systematic reviews related to children and adolescents’ oral health: A bibliometric analysis. Arquivos Em Odontologia, 59, 208–225.




Most read articles by the same author(s)