Reference intervals of creatinine and glycated hemoglobin parameters for the Brazilian adult population

National Health Survey

Authors

  • Ana Carolina Micheletti Gomide Nogueira de Sá Universidade Federal de Minas Gerais - UFMG, Escola de Enfermagem - EE, Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG - Brasil. https://orcid.org/0000-0002-0122-2727
  • Elton Junio Sady Prates Universidade Federal de Minas Gerais - UFMG, Escola de Enfermagem - EE, Programa de Pós-Graduação em Enfermagem. Belo Horizonte, MG - Brasil. https://orcid.org/0000-0002-5049-186X
  • Alexandra Dias Moreira Universidade Federal de Minas Gerais - UFMG, Escola de Enfermagem - EE, Departamento de Enfermagem Materno-Infantil e Saúde Pública. Belo Horizonte, MG - Brasil. https://orcid.org/0000-0002-4477-5241
  • Lilian Kelen Aguiar Hospital Risoleta Tolentino Neves - HRTN, Serviço de Controle de Infecção Hospitalar - SCIH. Belo Horizonte, MG - Brasil. https://orcid.org/0000-0001-9263-4198
  • Célia Landmann Szwarcwald Instituto de Comunicação e Informação Científica e Tecnológica em Saúde - ICICT, Fundação Oswaldo Cruz - FIOCRUZ. Belo Horizonte, MG - Brasil. https://orcid.org/0000-0002-7798-2095
  • Deborah Carvalho Malta Universidade Federal de Minas Gerais - UFMG, Escola de Enfermagem - EE, Departamento de Enfermagem Materno-Infantil e Saúde Pública. Belo Horizonte, MG - Brasil. https://orcid.org/0000-0002-8214-5734

DOI:

https://doi.org/10.35699/2316-9389.2022.40192

Keywords:

Reference Values, Creatinine, Glycated Hemoglobin A, Health Surveys, Risk Factors, Brazil

Abstract

Objective: to estimate reference intervals (RIs) of creatinine and glycated hemoglobin (HbA1c) in the Brazilian adult population. Methods: a cross-sectional study, using the National Health Survey (Pesquisa Nacional de Saúde, PNS) database, between 2014-2015, consisting of 8,952 adults. To establish RIs, exclusion criteria were applied, outliers were removed and stratification was performed. After these procedures, the sample consisted of 2,723 adults for HbA1c and 2,738 adults for creatinine. Differences were evaluated by means of the Mann Whitney and Kruskal Wallis tests (p≤0.05). Results: men (RI: 0.69-1.25; median: 0.95 mg/dL) had higher RIs for creatinine than women (RI: 0.53-1.05; median: 0.74 mg/dL) and higher lower limit (LL) values and median HbA1c (male: RI: 4.55-5.97; median: 5.3%; female: RI: 4.49-5.97; median: 5.20%) (p≤0.05). In women, the RIs for creatinine were higher in the age groups between 45 and 59 years old (RI: 0.55-1.04; median: 0.77 mg/dL) and from 60 years old (RI: 0.54-0.98; median: 0.77 mg/dL (p≤0.05). For HbA1c, men had higher RIs from age 60 (RI: 4.65-6.07; median: 5.44%) and women from 45 years old (45-59: RI: 4.61-6.05; median: 5.40%; and 60 years old or more: RI: 4.82-6.03; median: 5.50%) (p≤0.05). For creatinine, lower RI LLs and more prominent medians were observed in white-skinned adults (RI: 0.56-1.19; median: 0.85%) when compared to brown-skinned (RI: 0.55-1.19; median: 0.84%) (p≤0.05). Conclusion: appropriate RIs make it possible to unveil the health conditions of Brazilian adults and can support proper identification of chronic kidney disease and diabetes.

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Additional Files

Published

2022-12-28

How to Cite

1.
Sá ACMGN de, Prates EJS, Moreira AD, Aguiar LK, Szwarcwald CL, Malta DC. Reference intervals of creatinine and glycated hemoglobin parameters for the Brazilian adult population: National Health Survey. REME Rev Min Enferm. [Internet]. 2022 Dec. 28 [cited 2024 Jul. 17];26. Available from: https://periodicos.ufmg.br/index.php/reme/article/view/40192

Issue

Vol. 26 (2022)

Section

Research

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